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Báo cáo khoa học: Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose
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The structures of MornigaM and the MornigaM–mannose complex have been determined at 1.8 A˚ and 2.0 A˚ resolution, respectively. Both struc-tures adopt the typical b-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbo-hydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure–function rela-tionships within the small group of Moraceae lectins....
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