Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

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Signal transduction pathways are often embedded in com-plex networks, which result from interactions between pathways and feedback circuitry. In order to understand such networks, qualitative information on which inter-actions take place and quantitative data on their strength become essential. Here, we have investigated how the mul-tiple interactions between the mitogen-activated protein kinase cascade and protein kinase C (PKC) affect the time profile of extracellular signal-regulated kinase (ERK) phos-phorylation upon epidermal growth factor (EGF) stimula-tion in normal rat kidney fibroblasts....

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