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Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK

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The TEC family is ancient and constitutes the second largest family of cyto-plasmic tyrosine kinases. In 1993, loss-of-function mutations in theBTK gene were reported as the cause of X-linked agammaglobulinemia. Of all the existing 90 tyrosine kinases in humans, Bruton’s tyrosine kinase (BTK) is the kinase for which most mutations have been identified.

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