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Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes
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Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prosta-glandins that are major inflammatory agents. COX-2 production is trig-gered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE-1 in regula-ting the COX-2gene in response to endotoxin and other pro-inflammatory stimuli. We report that the induction of COX-2expression by lipopoly-saccharide (LPS) and pro-inflammatory cytokines correlates with ESE-1 induction in monocyte⁄macrophages. ...
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