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Báo cáo khoa học: The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding
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Antichymotrypsin, a member of the serpin superfamily, has been shown to form inactive polymers in vivo, leading to chronic obstructive pulmonary disease. At present, however, the molecular determinants underlying the polymerization transition are unclear.
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