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Báo cáo khoa học: Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:6

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The interaction of the antibacterial phosphonodipeptide alafosfalinwithmammalianH + /peptide cotransporters was studied in Caco-2 cells, expressing the low-affinity intestinal type peptide transporter 1 (PEPT1), and SKPT cells, expressing the high-affinity renal type peptide transporter 2 (PEPT2). Alafosfalin strongly inhibited the uptake of [ 14 C]glycylsarcosine withKi values of 0.19 ± 0.01 mMand 0.07 ± 0.01 mMfor PEPT1 and PEPT2, respectively.

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Nội dung Text: Báo cáo khoa học: Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells

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