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Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
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Recent reports have demonstrated that interactions between the microtu-bule-associated protein tau and the nonreceptor tyrosine kinase Fyn play a critical role in mediating synaptic toxicity and neuronal loss in response to b-amyloid (Ab) in models of Alzheimer’s disease.
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