Báo cáo khoa học: X-ray structure of peptidyl-prolyl cis–trans isomerase A from Mycobacterium tuberculosis
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Peptidyl-prolylcis–transisomerases (EC 5.2.1.8) catalyse the interconversion of cis and trans peptide bonds and are therefore considered to be important for protein folding. They are also thought to participate in processes such as signalling, cell surface recognition, chaperoning and heat-shock response. Here we report the soluble expression of recombinant Mycobacterium tuberculosispeptidyl-prolyl cis–transisomerasePpiAinEscherichiacoli, togetherwithan investigationof its structure andbiochemical properties....
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