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Báo cáo Y học: DNA and RNA damage by Cu(II)-amikacin complex

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Theoxidation-promotingreactivityof copper(II) complexof aminoglycosidic antibiotic amikacin [Cu(II)-Ami] in the presence of hydrogen peroxide, was studied at pH 7.4, using 2¢-deoxyguanosine (dG), pBR322 plasmid DNA and yeast tRNA Phe as target molecules. Themixtures of complexwith H2O2were found to be efficient oxidants, converting dG to its 8-oxo derivative, generating strand breaks in plasmid DNA and multiple cleavages in tRNA Phe .

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Nội dung Text: Báo cáo Y học: DNA and RNA damage by Cu(II)-amikacin complex

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