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Báo cáo Y học: Histidine mutagenesis of Arabidopsis thaliana pyruvate dehydrogenase kinase

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:6

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Pyruvate dehydrogenase kinase (PDK) is the primary regulator of flux through the mitochondrial pyruvate dehy-drogenase complex (PDC).Analysis of the primary amino-acid sequences of PDK from various sources reveals that these enzymes include the five domains characteristic of prokaryotic two-component His-kinases, despite the fact that PDKexclusivelyphosphorylates Ser residues in theE1a subunit of the PDC.This seeming contradiction might be resolved if the PDK-catalyzed reaction employed a phos-pho-His intermediate....

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Nội dung Text: Báo cáo Y học: Histidine mutagenesis of Arabidopsis thaliana pyruvate dehydrogenase kinase

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