Báo cáo Y học: Oxidative deamination of lysine residue in plasma protein of diabetic rats Novel mechanism via the Maillard reaction
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The levels ofa-aminoadipic-d-semialdehyde residue, the oxidative deamination product of lysine residue, in plasma protein from streptozotocin-induced diabetic rats were evaluated.a-Aminoadipic-d-semialdehyde was converted to a bisphenol derivative by acid hydrolysis in the presence of phenol, and determined by high performance liquid chro-matography. Analysis of plasma proteins revealed three timeshigherlevelsofa-aminoadipic-d-semialdehyde in dia-betic subjects comparedwithnormal controls.
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