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Báo cáo Y học: Regulation of mammalian translation factors by nutrients

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:12

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Protein synthesis requires both amino acids, as precursors, and a substantial amount of metabolic energy. It is well established that starvation or lack of nutrients impairs pro-tein synthesis in mammalian cells and tissues. Branched chain amino acids are particularly effective in promoting protein synthesis. Recent work has revealed important new information about the mechanisms involved in these effects. Anumber of components of the translational machinery are regulated through signalling events that require the mam-malian target of rapamycin, mTOR. ...

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