Báo cáo Y học: The N-terminus of m5C-DNA methyltransferase Msp I is involved in its topoisomerase activity
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DNA cytosine methyltransferaseMspI(M.MspI) must require a different type of interaction of protein with DNA from other bacterial DNA cytosine methyltransferases (m5C-MTases) to evoke the topoisomerase activity that it possesses in addition toDNA-methylation ability. Thismay require a different structural organization in the solution phase from the reported consensus structural arrangement for m5C-MTases.
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