Fabrication of in situ crosslinking hydrogels based on oxidized alginate/N,O-carboxymethyl chitosan/β-tricalcium phosphate for bone regeneration

In this study, hydrogels based on in situ crosslinking between oxidized alginate (OA) and N,Ocarboxymethyl chitosan (NOCC) in combination with β-tricalcium phosphate (β-TCP) were prepared using different OA concentrations and OA to NOCC ratios.