Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigenrelated cell adhesion molecules 5 and 6 in colorectal cancer cells

Colorectal cancer (CRC) is among the five most frequent causes for cancer-related deaths in Europe. One of the most important tumor-associated antigens for CRC is carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), which is involved in cell adhesion, migration, anoikis, tumor invasion and metastasis.