Synthesis of two new hydroximinosteroids from cholesterol and their biological evaluation

A simple and efficient synthesis of two new hydroximinosteroidal derivatives (11, 13) from cholesterol as starting material was described. The cytotoxicity of these compounds, their intermediates and two other known hydroximinosteroids were evaluated on human cancer cell lines including hepatocellular carcinoma (Hep-G2), cervical cancer (HeLa) and glioblastoma (T98G).