Addressing the challenges

This research is located spatially and conceptually within site-specific arts practice. There is a rich history here that began with the awakening of artists and institutions in the 1960s to the importance of the conditions of site (Kraus 1977). Here, the critical relationship between artist and their subject spaces set a challenge to how we engage with the environments in which we work and live.

135p runordie3 06-07-2022 0 0   Download

Few studies have addressed colon cancer surgery outcomes in an unselected cohort of octogenarian patients. The present study aimed to evaluate the relative survival of octogenarian patients after a major resection of colon cancer with a curative intent.

15p viangelamerkel 27-07-2022 1 1   Download

Advanced Computer Networks: Lecture 22. This lecture will cover the following: OSPF routing protocol; original ARPANET metric; how to make routing scale; mobile IP and challenges; flat versus hierarchical addresses;...

7p haoasakura 30-05-2022 7 1   Download

This paper is based on Literature, information and publications from relevant institutions, various Libraries and internet sources using descriptive method of study. ASEAN must address a number of environmental problem and challenges that may emerge as hindrances to the accomplishment of a clean and green ASEAN in ASEAN vision 2020.

12p visherylsandberg 18-05-2022 1 1   Download

In the past decades, scholars have addressed the importance of intermediary organizations as facilitators of technology transfer in an innovation system. They used the intermediary term in different contexts of the innovation system. Although many studies underlined the importance of intermediaries, there is not much discussion on the functions of intermediaries in the innovation system. This paper aims to highlight the importance of intermediaries in increasing the absorptive capacity of firms.

8p alucardhellsing 04-05-2022 8 1   Download

The rapidly aging societies worldwide and in Singapore present a unique challenge, requiring an integrated multidisciplinary approach to address high-value targets such as muscle health. We propose pragmatic evidence-based multidisciplinary consensus recommendations for the assessment and multi-modal management of muscle health in older adults (≥65 years) across the continuum of care.

14p vinobelprisen 26-03-2022 7 0   Download

Psychosocial issues, such as social isolation and loneliness among older adults and people with dementia, continue to pose challenges with a rapidly aging population worldwide. Social robots are a rapidly emerging field of technology, developed to help address the psychosocial needs of this population.

17p vinobelprisen 26-03-2022 1 0   Download

Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. Here we present SUPPA2, a new method that addresses these challenges, and enables streamlined analysis across multiple conditions taking into account biological variability.

11p vimichaelfaraday 25-03-2022 7 0   Download

Single-cell RNA-seq data contain a large proportion of zeros for expressed genes. Such dropout events present a fundamental challenge for various types of data analyses. Here, we describe the SCRABBLE algorithm to address this problem.

12p vigalileogalilei 27-02-2022 4 0   Download

Challenges are achieving broad acceptance for addressing many biomedical questions and enabling tool assessment. But ensuring that the methods evaluated are reproducible and reusable is complicated by the diversity of software architectures, input and output file formats, and computing environments.

9p vielonmusk 30-01-2022 3 0   Download

Studies of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular methods as well as culture-based methods exist for population-scale microbiome profiles. To link the resulting host and microbial data types to human health, several experimental design considerations, data analysis challenges, and statistical epidemiological approaches must be addressed.

16p vialfrednobel 29-01-2022 2 0   Download

On behalf of The Human Proteome Organization (HUPO) Proteomics Standards Initiative, we introduce here two novel standard data formats, proBAM and proBed, that have been developed to address the current challenges of integrating mass spectrometry-based proteomics data with genomics and transcriptomics information in proteogenomics studies.

8p vialfrednobel 29-01-2022 4 0   Download

Metastatic progress is the primary cause of death in most cancers, yet the regulatory dynamics driving the cellular changes necessary for metastasis remain poorly understood. Multi-omics approaches hold great promise for addressing this challenge; however, current analysis tools have limited capabilities to systematically integrate transcriptomic, epigenomic, and cistromic information to accurately define the regulatory networks critical for metastasis.

28p viarchimedes 26-01-2022 5 0   Download

Generating chromosome-level, haplotype-resolved assemblies of heterozygous genomes remains challenging. To address this, we developed gamete binning, a method based on single-cell sequencing of haploid gametes enabling separation of the whole-genome sequencing reads into haplotype-specific reads sets.

20p viarchimedes 26-01-2022 3 0   Download

Investigating genome evolution in response to therapy is difficult in human tissue samples. To address this challenge, we develop an unbiased wholegenome plasma DNA sequencing approach that concurrently measures genomic copy number and exome mutations from archival cryostored plasma samples.

22p viarchimedes 26-01-2022 3 0   Download

The article aims to explore the extent to which the implementation of CBC is being impeded by challenges currently being experienced in the initial stages of implementation. It is therefore the thesis of the article that any impediments to this transformation agenda should be addressed speedily in order for learners to benefit optimally from the new changes.

8p lazzaro 30-12-2021 3 0   Download

If this challenge of global warming is not addressed we are bound to see and experience more environmental hazards to human health, such as extreme weather, ozone depletion, increased danger of wild land fires, loss of biodiversity, stresses to food – producing systems and the global spread of infectious diseases. In addition climate change is estimated to cause around 150, 000 deaths globally each year.

7p mudbound 06-12-2021 1 0   Download

Adult patients with cystic fibrosis (CF) experience daily physical symptoms and disabilities that can be challenging to address for health care teams. Methods: We sought to identify the most frequent topics that CF adults need to discuss with health care teams using a custom questionnaire including 62 items.

8p vimackenziebezos 29-11-2021 2 0   Download

The East Sea and its resources play a crucial role in Vietnam’s 2030 and vision to 2045 development agenda. This new “marine economy” model brings with its enormous opportunities, but also challenges that need to be address for its effective implementation especially under the complex geopolitical situation in the East Sea.

13p inception36 30-11-2021 1 0   Download

One of the most challenging problems in colorectal cancer (CRC) is resistance to chemotherapy drugs such as doxorubicin (DOX). The programmed death ligand-1 (PD-L1) is related to chemoresistance and is overexpressed in several human cancer cell types. Here, we investigated the changes in the expression of PD-L1 in DOX-treated CRC and breast cancer (BRC) cells. Also, to address PD-L1 regulation, we assessed expression levels of miR-140 and miR-34a, two microRNAs that can target the 3’ UTR region of the gene encoding PD-L1.

9p thiencuuchu 27-11-2021 1 0   Download