Administration of drugs

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. This study aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour. Four different brands of nasal spray were investigated.

91p runthenight04 02-02-2023 8 3   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. The thesis "Experimental Studies in Aid of Improving Nasal Drug Delivery" aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour.

91p runordie3 06-07-2022 5 3   Download

Cisplatin (CP) is considered one of the most effective and widely used anti-neoplastic drug in the treatment of different solid organ tumors. The present study was carried out to assess the hematological changes following CP administration in Wistar albino rats and its amelioration by extract of Andrographis paniculata (AP). The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group.

8p angicungduoc6 22-07-2020 9 1   Download

Aripiprazole is a widely used antipsychotic approved by the FDA (Food and Drug Administration) in 2002. Methods for preparation of aripiprazole mainly involve the use of expensive and toxic solvents, and the reaction time can be even several hours long.

6p tocectocec 25-05-2020 11 1   Download

Development of optimized pediatric formulations for oral administration can be challenging, time consuming, and financially intensive process. Since its inception, the biopharmaceutical classification system (BCS) has facilitated the development of oral drug formulations destined for adults. At least theoretically, the BCS principles are applied also to pediatrics. A comprehensive age-appropriate BCS has not been fully developed.

9p caothientrangnguyen 09-05-2020 36 3   Download

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinical characterization of the pharmacokinetics of AR-42 in mice and rats.

9p caothientrangnguyen 09-05-2020 18 3   Download

Purpose: Based on theoretical studies of state management on the prevention of drugs, analysis and assessment of the state of the state management on the prevention of drugs in Vietnam, fellows establish and implement the scientific foundation to propose practical solutions to improve system ef ciency of state management on the prevention of drugs in Vietnam during the integration period.

28p change01 05-05-2016 52 4   Download

Mẫu giấy phép nhập khaur bằng tiếng anh - Import licence MINISTRY OF PUBLIC SECURITY Social Republic of VIETNAM Standing Office on Crime and Drugs Control -------IMPORT LICENCE --------------- No. ............................. Hanoi, date......................................... Standing Office on Crime and Drugs Control of ministry of Public Security here by certify that: Institute of Forensic Science, Ministry of Public Security Being the authority charged with the administration of the relating to the drugs to with the 1961, 1971, 1988 conventions apply: ...

1p banhbeonhanthit 31-07-2013 86 7   Download

The Hsp90 molecular chaperone catalyses the final activa-tion step of many of themost important regulatory proteins of eukaryotic cells. The antibiotics geldanamycin and rad-icicol act as highly selective inhibitors of in vivo Hsp90 function through their ability to bindwithin the ADP/ATP binding pocket of the chaperone. Drugs based on these compounds are now being developed as anticancer agents, their administration having the potential to inactivate sim-ultaneously several of the targets critical for counteracting multistep carcinogenesis. ...

7p fptmusic 12-04-2013 42 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance...

3p thulanh16 22-10-2011 49 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug

4p matuot_238 13-10-2011 59 2   Download

Thuốc chích Lucentis giúp cho thị giác người già bị suy thoái võng mạc có thể nhìn thấy được 90%. Đây là một phân tử chưa được đưa ra thị trường trước đây. FDA Approves New Biologic Treatment for Wet Age-Related Macular Degeneration The Food and Drug Administration (FDA) today approved Lucentis (ranibizumab injection) for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD) Lucentis is the first treatment which, when dosed monthly, can maintain the vision of more than 90 percent of patients with this type of AMD. ...

4p nganluong111 14-04-2011 107 4   Download

Đây là lần đầu tiên, FDA cho dùng thuốc trị ưu trầm thay đổi theo mùa, nhiều nhất về mùa Đông. Những công phạt của Wellbutrin XL như cơ thể kích thích, buồn bã, khó ngủ. Thử nghiệm cho thấy thuốc tương đối an toàn trị bệnh ưu trầm thay đổi theo mùa. (Xin đọc phần cuối: Ưu Trầm Trong Mùa Ðông, Trần Mạnh Ngô, M.D., Ph.D.) FDA Approves the First Drug for Seasonal Depression The Food and Drug Administration (FDA) today approved Wellbutrin XL for prevention of major depressive episodes in patients with a history of seasonal affective...

7p nganluong111 14-04-2011 65 2   Download

FDA Licenses New Vaccine to Reduce Older Americans’ Risk of Shingles The Food and Drug Administration (FDA) licensed Zostavax, on May 25, 2006, a new vaccine to reduce the risk of shingles (herpes zoster) for use in people 60 years of age and older. "This vaccine gives health care providers an important tool that can help prevent an illness that affects many older Americans and often results in significant chronic pain," said Jesse L. Goodman, MD, MPH, Director of FDA's Center for Biologics Evaluation and Research.

3p nganluong111 14-04-2011 62 3   Download

FDA cho phép dùng thuốc mới Remicade (infliximab) cho việc điều trị bệnh viêm ruột Crohn’s disease. Remicade là một loại thuốc do điều chế kháng thể đơn dòng (monoclonal antibody). Thuốc giảm hiện tượng viêm bằng cách ngăn chặn yếu tố tumor necrosis factor-alpha (TNF-alpha). FDA Approves Remicade for Children with Crohn’s Disease The Food and Drug Administration today approved Remicade (infliximab) to treat children with active Crohn's disease, a chronic, inflammatory condition of the bowel that can be severely debilitating.

7p nganluong111 14-04-2011 105 5   Download