Agonistic signals
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Part 2 book "Animal signaling and function - An integrative approach" includes content: Agonistic signals - Integrating analysis of functions and mechanisms, acoustic signal evolution - biomechanics, size, and performance; dishonest signaling during aggressive interactions - theory and empirical evidence; functional approach to condition.
133p oursky07 24-10-2023 6 5 Download
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The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respectively. This study aims to investigate whether BMP4 can mediate the interaction of CRC with T2DM.
15p vioracle 29-09-2023 5 2 Download
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Gonadotropin-releasing hormone (GnRH) receptor, a rhodopsin-like G-protein coupled receptor (GPCR) family member involved in GnRH signalling, is reported to be expressed in several tumors including glioblastoma multiforme (GBM), one of the most malignant and aggressive forms of primary brain tumors.
12p vipriyankagandhi 27-07-2022 3 2 Download
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ErbB4/HER4 is a unique member of the ErbB family of receptor tyrosine kinases concerning its activation of anti-proliferative JAK2-STAT5 pathway when stimulated by ligand Neuregulin (NRG). Activation of this pathway leads to expression of genes like β-casein which promote cell differentiation.
14p vijisoo2711 27-10-2020 5 0 Download
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In airways, a proliferative effect is played directly by cholinergic agonists through nicotinic and muscarinic receptors activation. How tumors respond to aberrantly activated cholinergic signalling is a key question in smoking-related cancer.
13p vialabama2711 21-09-2020 13 1 Download
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MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers.
9p vikuala271 13-06-2020 14 0 Download
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The discovery that not all agonists uniformly activate cellular signaling pathways (biased signaling) has greatly changed the drug discovery process for agonists and the strategy for treatment of disease with agonists.
8p viorochimaru2711 30-05-2020 7 1 Download
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Effect of airway acidosis and alkalosis on airway vascular smooth muscle responsiveness to albuterol
In vitro and animal experiments have shown that the transport and signaling of β2-adrenergic agonists are pH-sensitive. Inhaled albuterol, a hydrophilic β2-adrenergic agonist, is widely used for the treatment of obstructive airway diseases.
7p vienzym2711 03-04-2020 7 1 Download
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The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. Commitment to osteogenesis is associated with activation of osteoblast-related signal transduction, whereas inactivation of this signal transduction favors adipogenesis.
13p viwashington2711 04-12-2019 10 1 Download
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Defining how the agonist–receptor interaction differs from that of the antagonist–receptor and understanding the mechanisms of receptor activation are fundamental issues in cell signalling. The V1a vasopressin receptor (V1aR) is a member of a family of related G-protein coupled receptors that are activated by neurohypophysial peptide hormones, including vasopressin (AVP). It has recently been reported that anarginyl in the distalN-terminus of theV1a Riscritical for binding agonists but not antagonists....
8p fptmusic 12-04-2013 28 2 Download
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As it has not yet been established whether the second messengers involved in the neutrophil response have identical or specific signalling requirements for each physiological function, protein kinase C (PKC) isoforms and mito-gen activated protein kinases (MAPKs) were studied in human chemotaxis triggered by the full agonist for-Met-Leu-Phe-OMe (fMLP-OMe) and the ‘pure’ chemoattractant for-Thp-Leu-Ain-OMe [Thp1,Ain3] analogue. Experiments were performed in the presence or absence of extracellular Ca 2+ , known to be an important modulator of second messengers....
0p awards 05-04-2013 37 1 Download
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Determinants for desensitization and sequestration of G protein-coupled receptors often contain serine or threonine residues located in their C-ter-mini. The sequence context, however, in which these residues have to appear, and the receptor specificity of these motifs are largely unknown.
12p awards 05-04-2013 43 2 Download
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When nucleotide hydrolysis is prevented, agonists of the P2Y12 receptor enhance the proliferation of C6 glioma cells by RhoA-dependent, protein kinase C (PKC)-dependent activation of the extracellular signal-regulated kinase (ERK) pathway [Claes P, Grobben B, Van Kolen K, Roymans D & Slegers H (2001)Br J Pharmacol134, 402–408; Grobben B, Claes P, Van Kolen K, Roymans D, Fransen P, Sys SU & Slegers H (2001)J Neurochem 78, 1325–1338].
12p inspiron33 26-03-2013 35 4 Download
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Using a more control-oriented terminology, the point-to-point motion task is a stabilization problem for an (equilibrium) point in the robot state space. For a car-like robot, two control inputs are available for adjusting four conguration variables, namely the two cartesian coordinates characterizing the position of a reference point on the vehicle, its orientation, and the steering wheels angle. More in general, for a car-like robot towing N trailers, we have two inputs for reconguring n = 4+N states.
29p nhacchovina 23-03-2013 50 4 Download
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b-Adrenergic receptor (b-AR)-induced cardiac remodeling is closely linked with the re-expression of the atrial natriuretic factor (ANF) gene. How-ever, the exact molecular mechanism of this response remains elusive. Here, we demonstrate that theb-AR agonist isoproterenol potently evokes the tyrosine phosphorylation of STAT3 and increases its transcriptional...
8p galaxyss3 07-03-2013 33 2 Download
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CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5a-androstane-3b,17b-diol (3b-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones. Previous studies have suggested that CYP7B1-dependent metab-olism involving dehydroepiandrosterone or 3b-Adiol may play an impor-tant role for estrogen receptor b-mediated signaling.
12p media19 06-03-2013 40 1 Download
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Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery.
211p hyperion75 18-01-2013 47 4 Download
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Several hematopoietic growth factors (HGFs) have achieved widespread clinical application. In the United States alone, more than US $5 billion per year of the health care budget is spent on these factors. The first patients were treated with recombinant human erythropoietin (rHuEPO, epoetin alfa, Epogen®) in 1985 and the first patients received recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF, filgrastim, Neupogen®) or recombinant human granulocyte-macrophage colonystimulating factor (rHuGM-CSF, sargramostim, Leukine® or Prokine®) in 1986.
489p hyperion75 18-01-2013 54 6 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation...
15p toshiba11 19-10-2011 45 2 Download
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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists...
19p toshiba3 07-09-2011 69 3 Download