Analysis in gis

Lysophosphatidicacid (LPA), oneof thenaturallyoccurring phospholipids, stimulates cellmotility through theactivation of Rho family members, but the signaling mechanisms remain tobe elucidated. In thepresent study,we investigated the roles of p21-activated kinase 1 (PAK1) onLPA-induced focal adhesion kinase (FAK) phosphorylation and cell motility.

9p dell39 03-04-2013 35 3   Download

Accumulating evidence indicates that G protein signaling plays an active role in the regulation of cell survival. Our previous study demonstrated the regulatory effects of Gi⁄ o proteins in nerve growth factor-induced activa-tion of pro-survival Akt kinase. In the present study we explored the role of various members of the Gs,Gq⁄ 11 and G12⁄ 13 subfamilies in the regula-tion of Akt in cultured mammalian cells.

11p inspiron33 26-03-2013 46 4   Download

Pasteurella multocidatoxin (PMT) is a virulence factor responsible for the pathogenesis of somePasteurellosis. PMT exerts its toxic effects through the activation of heterotrimeric GTPase (Gq,G12⁄ 13 and Gi )-dependent pathways, by deamidating a glutamine residue in theasubunit of these GTPases.

13p cosis54 05-01-2013 37 5   Download