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Báo cáo khoa học: Constitutively active a subunits of Gq/11 and G12/13 families inhibit activation of the pro-survival Akt signaling cascade

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Accumulating evidence indicates that G protein signaling plays an active role in the regulation of cell survival. Our previous study demonstrated the regulatory effects of Gi⁄ o proteins in nerve growth factor-induced activa-tion of pro-survival Akt kinase. In the present study we explored the role of various members of the Gs,Gq⁄ 11 and G12⁄ 13 subfamilies in the regula-tion of Akt in cultured mammalian cells.

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Nội dung Text: Báo cáo khoa học: Constitutively active a subunits of Gq/11 and G12/13 families inhibit activation of the pro-survival Akt signaling cascade

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