Antibacterial

Keeping the background in view, the present study was designed to determine the antibacterial action of enrofloxacin alone and in combination with phytochemicals capsaicin, theobromine, glycyrrhetenic acid and glycyrrhizic acid against S. aureus ATCC 25923, E.coli ATCC 25922, K. pneumoniae ATCC 700603 and P. aeruginosa ATCC 27853.

6p chauchaungayxua11 23-03-2021 9 2   Download

A new series of transition metal complexes of Co(III), Ni(II) and VO(IV) was synthesized with the bidentate Schiff base ligand (HL) derived from the condensation of 2-amino-3-benzyloxypyridine and 5-bromo salicylaldehyde.

14p tocectocec 25-05-2020 23 2   Download

A group of new fluoroaniline Schiff bases (3a–3f) were synthesized and structurally characterized by various spectroscopic techniques such as 1H-NMR, LC-MS and FT-IR spectral studies.

8p tocectocec 25-05-2020 16 1   Download

A series of novel 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine linked various sulfonamide derivatives 8a-8j poly functionalized were designed and synthesized in moderate to good yield.

10p tocectocec 25-05-2020 14 1   Download

The thesis aims to successfully fabricate NaHAp films doped separately and simultaneously with microelements: sodium, magnesium, strontium, fluorine, copper, silver and zinc on 316L stainless steel substrate to meet the requirement of screw bracing bone. Study on physicochemical characteristics, study on toxicity, antibacterial ability and bio-compatibility of NaHAp films separately and concurrently with trace elements.

27p xacxuoc4321 11-07-2019 20 3   Download

Ethanolic and aqueous (hot and cold) extracts of the fruit pulp, stem bark and leaves of Tamarindus indica were evaluated for antibacterial activity, in vitro, against 13 Gram negative and 5 Gram positive bacterial strains using agar well diffusion and macro broth dilution techniques, simultaneously.

12p tanbnhp 22-03-2014 47 6   Download

Two novel pore-forming peptides have been isolated from the venom of the South-African scorpion Opistophtalmus carinatus. These peptides,designated opistoporin 1 and 2, differ by only one amino acid and belong to a group of a-helical,cationic peptides. For the first time,a comparison of the primary structures ofa-helical pore-forming peptides from scorpion venom was undertaken.

12p research12 29-04-2013 43 3   Download

Members of the proline-rich antibacterial peptide family, pyrrhocoricin, apidaecin and drosocin appear to kill responsive bacterial species by binding to themultihelical lid region of the bacterial DnaK protein.Pyrrhocoricin, the most potent among these peptides, is nontoxic to healthy mice, andcanprotect these animals frombacterial challenge.

12p research12 23-04-2013 33 3   Download

Antibacterial peptides were isolated fromhuman peripheral granulocytes of a healthy donor who had been treated with granulocyte-colony stimulating factor (G-CSF) and cortisol. Peptides were solubilized in acidi®ed chloroform/methanol, and partitioned in chloroform/methanol/water. Water-soluble polypeptides were separated by cation-exchange and reversed-phase chromatography. Several previously char-acterized antibacterial polypeptides were identi®ed; defen-sins 1±3, defensin 4, lysozyme, eosinophil cationic protein, and calgranulin A. ...

7p research12 23-04-2013 26 3   Download

Microcin J25 (MccJ25) is the single macrocyclic antimicro-bial peptidebelonging to the ribosomally synthesizedclass of microcins that are secreted byEnterobacteriaceae.Itshowed potent antibacterial activity against severalSalmonellaand Escherichiastrains and exhibited a compact three-dimen-sional structure [Blondet al. (2001) Eur. J. Biochem., 268, 2124–2133]. The molecular mechanisms involved in the biosynthesis, folding andmode of action of MccJ25 are still unknown.

11p tumor12 22-04-2013 44 2   Download

Peptides composed of leucyl and lysyl residues (
LK pep-tides) with different compositions and sequences were compared for their antibacterial activities usingcell wall-less bacteria of the classMollicutes(acholeplasmas, mycoplas-mas and spiroplasmas) as targets. The antibacterial activity of the amphipathica-helical peptides varied with their size, 15 residues beingthe optimal length, independent of the membrane hydrophobic core thickness and the amount of cholesterol.

11p fptmusic 16-04-2013 37 3   Download

The interaction of the antibacterial phosphonodipeptide alafosfalinwithmammalianH + /peptide cotransporters was studied in Caco-2 cells, expressing the low-affinity intestinal type peptide transporter 1 (PEPT1), and SKPT cells, expressing the high-affinity renal type peptide transporter 2 (PEPT2). Alafosfalin strongly inhibited the uptake of [ 14 C]glycylsarcosine withKi values of 0.19 ± 0.01 mMand 0.07 ± 0.01 mMfor PEPT1 and PEPT2, respectively.

6p dell39 03-04-2013 46 5   Download

Cationic antimicrobial peptides are naturally occurring antibiotics that are actively being explored as a new class of anti-infective agents. We recently identified three cathelicidin antimicrobial peptides from chicken, which have potent and broad-spectrum antibacterial activitiesin vitro (Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE & Zhang G (2006)J Biol Chem281, 2858–2867).

13p inspiron33 26-03-2013 50 4   Download

Antimicrobial peptides are effector molecules of the innate immune system. We have recently shown that peptides containing multiples of the heparin-binding Cardin and Weintraub motifs AKKARA and ARKKAAKA exert antimicrobial activities. Here, we show that replacement of lysine and arginine in these motifs by histidine abrogates the antibacterial effects of these peptides.

8p inspiron33 26-03-2013 48 4   Download

Cathelicidins are an important family of cationic host defense peptides in vertebrates with both antimicrobial and immunomodulatory activities. Fowlicidin-1 and fowlicidin-2 are two newly identified chicken cathelicidins with potent antibacterial activities. Here we report structural and func-tional characterization of the putatively mature form of the third chicken cathelicidin, fowlicidin-3, for exploration of its therapeutic potential.

11p inspiron33 23-03-2013 40 3   Download

Histidine-rich glycoprotein (HRGP), an abundant heparin-binding protein found in plasma and thrombocytes, exerts antibacterial effects against Gram-positive bacteria (Enterococcus faecalisand Staphylococcus aureus) and Gram-negative bacteria (Escherichia coliandPseudomonas aeruginosa). Fluorescence studies and electron microscopy to assess membrane permea-tion showed that HRGP induces lysis of E.

13p inspiron33 23-03-2013 49 5   Download

Fish skin mucus contains a variety of antimicrobial proteins and peptides that seem to play a role in self defense. We previously reported an antibac-terial protein in the skin secretion of the rockfish, Sebastes schlegeli, which showed selective antibacterial activity against Gram-negative bacteria. This study aimed to isolate and structurally and functionally characterize this protein.

12p inspiron33 23-03-2013 47 4   Download

Hexameric DnaB helicase unwinds the DNA double helix during replica-tion of genetic material in bacteria. DnaB is an essential bacterial protein; therefore, it is an important potential target for antibacterial drug disco-very. We report a crystal structure of the N-terminal region of DnaB from the pathogen Mycobacterium tuberculosis(MtDnaBn), determined at 2.0 A˚ resolution.

8p galaxyss3 07-03-2013 50 4   Download

Trappin-2 (also known as pre-elafin) is an endogenous inhibitor of neutro-phil serine proteases and is involved in the control of excess proteolysis, especially in inflammatory events, along with the structurally related secre-tory leucocyte proteinase inhibitor.

13p media19 06-03-2013 42 4   Download

Eppin has two potential protease inhibitory domains: a whey acid protein or four disulfide core domain and a Kunitz domain. The protein is also reported to have antibacterial activity against Gram-negative bacteria. Eppin and its whey acid protein and Kunitz domains were expressed in Escherichia coliand their ability to inhibit proteases and kill bacteria compared.

9p media19 06-03-2013 26 1   Download