Bone metastases

Evaluate the effectiveness of pain relief due to bone metastasis using external beam radiation therapy technique. Subjects and Methods: Retrospective and prospective study describing 178 patients with stage IV cancer, bone metastases, treated for pain relief with external radiotherapy, at the Institute of Oncology and Nuclear Medicine, Hospital Military Medicine 175, from May 2021 to April 2022.

9p viavatis 29-08-2024 3 1   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pain in castration-resistant prostate cancer with bone metastases: a qualitative study

11p panasonic05 22-12-2011 56 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Bone metastases mimicking Complex Regional Pain Syndrome I: a case report

4p thulanh30 20-12-2011 39 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles

11p toshiba17 28-10-2011 55 3   Download

Etiology Humoral hypercalcemia of malignancy (HHM) occurs in up to 20% of patients with cancer. HHM is most common in cancers of the lung, head and neck, skin, esophagus, breast, genitourinary tract, and in multiple myeloma and lymphomas. Several distinct humoral causes of HHM occur, most commonly overproduction of PTHrP. In addition to acting as a circulating humoral factor, bone metastases (e.g., breast, multiple myeloma) may produce PTHrP, leading to local osteolysis and hypercalcemia.

5p thanhongan 07-12-2010 79 3   Download

Chondrosarcoma Chondrosarcoma, which constitutes ~20–25% of all bone sarcomas, is a tumor of adulthood and old age with a peak incidence in the fourth to sixth decades of life. It has a predilection for the flat bones, especially the shoulder and pelvic girdles, but can also affect the diaphyseal portions of long bones. Chondrosarcomas can arise de novo or as a malignant transformation of an enchondroma or, rarely, of the cartilaginous cap of an osteochondroma. Chondrosarcomas have an indolent natural history and typically present as pain and swelling.

5p konheokonmummim 03-12-2010 69 4   Download

Cancer in the bone may produce osteolysis, osteogenesis, or both. Osteolytic lesions result when the tumor produces substances that can directly elicit bone resorption (vitamin D–like steroids, prostaglandins, or parathyroid hormone–related peptide) or cytokines that can induce the formation of osteoclasts (interleukin 1 and tumor necrosis factor). Osteoblastic lesions result when the tumor produces cytokines that activate osteoblasts. In general, purely osteolytic lesions are best detected by plain radiography, but they may not be apparent until they are 1 cm.

5p konheokonmummim 03-12-2010 102 4   Download

Stage Grouping Stage IA T1 N0 M0 G1,2 low grade Stage IB T2 N0 M0 G1,2 low grade Stage IIA T1 N0 M0 grade G3,4 high Stage IIB T2 N0 M0 G3,4 high grade Stage III T3 N0 M0 Any G Stage IVA T Any N0 M1a Any G Stage IVB T Any N1 M Any Any G Any T N Any M1b Any G Osteosarcoma Osteosarcoma, accounting for almost 45% of all bone sarcomas, is a spindle cell neoplasm that produces osteoid (unmineralized bone) or bone.

4p konheokonmummim 03-12-2010 86 4   Download

Bone Sarcomas Incidence and Epidemiology Bone sarcomas are rarer than soft tissue sarcomas; they accounted for only 0.2% of all new malignancies and 2370 new cases in the United States in 2007. Several benign bone lesions have the potential for malignant transformation. Enchondromas and osteochondromas can transform into chondrosarcoma; fibrous dysplasia, bone infarcts, and Paget's disease of bone can transform into either malignant fibrous histiocytoma or osteosarcoma.

5p konheokonmummim 03-12-2010 93 4   Download

Disease Stage 5-Year Survival, % Stage I 98.8 A: G1,2; T1a,b; N0; M0 B: G1,2; T2a; N0; M0 Stage II 81.8 A: G1,2; T2b; N0; M0 B: G3,4; T1; N0; M0 C: G3,4; T2a; N0; M0 Stage III G3,4; T2b; N0; M0 51.7 Stage IV

5p konheokonmummim 03-12-2010 129 4   Download

Tham khảo tài liệu 'chapter 094. soft tissue and bone sarcomas and bone metastases (part 2)', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

5p konheokonmummim 03-12-2010 100 3   Download

Classification Approximately 20 different groups of sarcomas are recognized on the basis of the pattern of differentiation toward normal tissue. For example, rhabdomyosarcoma shows evidence of skeletal muscle fibers with cross-striations; leiomyosarcomas contain interlacing fascicles of spindle cells resembling smooth muscle; and liposarcomas contain adipocytes. When precise characterization of the group is not possible, the tumors are called unclassified sarcomas. All of the primary bone sarcomas can also arise from soft tissues (e.g., extraskeletal osteosarcoma).

5p konheokonmummim 03-12-2010 99 7   Download

Metastatic Disease: Castrate Castration-resistant disease can manifest in many ways. For some it is a rise in PSA with no change in radiographs and no new symptoms. In others it is a rising PSA and progression in bone with or without symptoms of disease. Still others will show soft tissue disease with or without osseous metastases, and others have visceral spread. The prognosis, which is highly variable, can be predicted using nomograms designed for the castration-resistant disease state.

5p konheokonmummim 03-12-2010 75 4   Download

Staging of Small Cell Lung Cancer Pretreatment staging for patients with SCLC includes the initial general lung cancer evaluation with chest and abdominal CT scans (because of the high frequency of hepatic and adrenal involvement) as well as fiberoptic bronchoscopy with washings and biopsies to determine the tumor extent before therapy; brain CT scan (10% of patients have metastases); and radionuclide scans (bone) if symptoms or other findings suggest disease involvement in these areas.

7p konheokonmummim 03-12-2010 107 8   Download

Table 47-2 Causes of Hypocalcemia Low Parathyroid Hormone Levels (Hypoparathyroidism) Parathyroid agenesis Isolated DiGeorge syndrome Parathyroid destruction Surgical Radiation Infiltration by metastases or systemic diseases Autoimmune Reduced parathyroid function Hypomagnesemia Activating CaSR mutations High Parathyroid Hormone Levels (Secondary Hyperparathyroidism) Vitamin D deficiency or impaired 1,25(OH)2D production/action Nutritional vitamin D deficiency (poor intake or absorption) Renal insufficiency with impaired 1,25(OH)2D production Vitamin D resistance, inclu...

5p ongxaemnumber1 29-11-2010 70 4   Download

Table 47-1 Causes of Hypercalcemia Excessive PTH production Primary hyperparathyroidism (adenoma, hyperplasia, rarely carcinoma) Tertiary hyperparathyroidism (long-term stimulation of PTH secretion in renal insufficiency) Ectopic PTH secretion (very rare) Inactivating mutations in the CaSR (FHH) Alterations in CaSR function (lithium therapy) Hypercalcemia of malignancy Overproduction of PTHrP (many solid tumors) Lytic skeletal metastases (breast, myeloma) Excessive 1,25(OH)2D production Granulomatous diseases (sarcoidosis, tuberculosis, silicosis) Lymphomas Vitamin D intoxic...

5p ongxaemnumber1 29-11-2010 67 3   Download