![](images/graphics/blank.gif)
Cathepsin K
-
The main aim of the current study is to determine sufficient RANKL/MCSF concentrations for differentiation of the cells to osteoclasts and to describe the repressive effect of MEL on the osteoclastogenesis of these cells. In this regard, it was found that 10 ng/mL of RANKL- and MCSF-containing medium is suitable for inducing osteoclastogenesis of the cells. In addition, melatonin at doses in the range of 100–1000 µM does not have a cytotoxic effect.
10p
thiencuuchu
27-11-2021
7
2
Download
-
Selective and reversible inhibitors of human Cathepsin K (CatK), including odanacatib (ODN), have been developed as potential therapeutics for the treatment of osteoporosis. Inhibitors of human CatK show significantly less potency for the rodent enzymes compared with that for the human or rabbit enzymes.
9p
viannito2711
20-04-2021
6
2
Download
-
ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in the morning during the study, simulation can allow the antiresorptive effect to be assessed over 24 h, with assessment of the relationship to BMD gain.
9p
vitennessee2711
02-02-2021
10
2
Download
-
Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizing cathepsin K inhibitors.
19p
vinaypyidaw2711
26-08-2020
10
1
Download
-
Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma
Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning of oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute a family of proteolytic enzymes with known role in the degradation of the extracellular matrix.
9p
vibaku2711
22-07-2020
12
2
Download
-
Macrophages at an inflammatory site release massive amounts of proteolytic enzymes, including lysosomal cys-teine proteases, which colocalizewith their circulating, tight-binding inhibitors (cystatins, kininogens), so modifying the protease/antiprotease equilibrium in favor of enhanced proteolysis. We have explored the ability of human cath-epsins B, KandL to participate in the production of kinins, using kininogens and synthetic peptides that mimic the insertion sites of bradykinin on human kininogens....
8p
tumor12
20-04-2013
40
3
Download
-
Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells
Cystatin F is a recently discovered type II cystatin expressed almost exclu-sively in immune cells. It is present intracellularly in lysosome-like vesicles, which suggests a potential role in regulating papain-like cathepsins involved in antigen presentation. Therefore, interactions of cystatin F with several of its potential targets, cathepsins F, K, V, S, H, X and C, were studied in vitro. Cystatin F tightly inhibited cathepsins F, K and V with Ki values ranging from 0.17 nmto 0.35 nm, whereas cathepsins S and H were inhib-ited with 100-fold lower affinities (Ki 30 nm).
11p
awards
06-04-2013
44
2
Download
-
The recombinant cysteine peptidases, cruzain from Trypanosoma cruziand CPB2.8DCTE fromLeishmania mexicana, are cathepsin L-like and characteristically endo-peptidases. In this study, we characterized the carboxydi-peptidase activities of these enzymes and compared them with those of human recombinant cathepsin B and cathep-sin L. The analysis used the internally quenched fluorescent peptide Abz-FRFK*-OH and some of its analogues, where Abz isortho-aminobenzoic acid and K* is (2,4-dinitrophe-nyl)-e-NH2-lysine. ...
8p
dell39
03-04-2013
33
3
Download
-
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer
13p
dauphong8
14-01-2012
39
4
Download
-
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer
13p
dauphong6
05-01-2012
40
6
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-β...
13p
toshiba14
22-10-2011
52
3
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-B ligand...
7p
thulanh16
22-10-2011
44
2
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis...
12p
toshiba12
21-10-2011
32
2
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The effect of cathepsin K deficiency on airway development and TGF-b1 degradation...
14p
toshiba11
20-10-2011
36
3
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases...
12p
thulanh12
13-10-2011
59
4
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Serum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction...
6p
thulanh12
13-10-2011
42
3
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)