CD8 T cells
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In recent years, there has been extensive research on the role of exercise as an adjunctive therapy for cancer. However, the potential mechanisms underlying the anti-tumor therapy of exercise in lung cancer remain to be fully elucidated. As such, our study aims to confirm whether exercise-induced elevation of epinephrine can accelerate CD8+ T cell recruitment through modulation of chemokines and thus ultimately inhibit tumor progression.
16p vishanshan 27-06-2024 2 1 Download
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Metastatic disease is a major and difficult-to-treat complication of lung cancer. Considering insufficient effectiveness of existing therapies and taking into account the current problem of lung cancer chemoresistance, it is necessary to continue the development of new treatments.
14p vishanshan 27-06-2024 2 1 Download
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Although immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer dendritic cells (IKDCs) exhibit cytotoxicity and present antigens to relevant cells; thus, they can selectively induce tumor-associated antigen (TAA)-specific CD8 T cells and may be useful in cancer treatment.
12p vishanshan 27-06-2024 3 1 Download
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HBV infection is the leading risk factor for HCC. HBV infection has been confirmed to be associated with the exhaustion status of CD8+ T cells and immunotherapeutic efficacy in HCC. In this study, we aimed to investigate the prognostic value of the CD8+ T-cell exhaustion signature and immunotherapy response in patients with HBV-related HCC.
15p vishanshan 27-06-2024 1 1 Download
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PD-L1 showed abnormal mRNA and protein expression in a variety of cancers and predicted prognosis in cancer patients. Furthermore, across a variety of cancer types, the aberrant PD-L1 expression was connected to the MSI, MMR, TMB, drug sensitivity, and tumor immune microenvironment (TIME). Moreover, PD-L1 was significantly correlated with infiltrating levels of immune cells (T cell CD8+, neutrophil, and so on).
19p vishanshan 27-06-2024 1 1 Download
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CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8+ Tregs and their interaction with CD8+ T cells in the tumor microenvironment of human lung cancer.
12p vishanshan 27-06-2024 1 1 Download
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Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of AMPKα2 in the LIHC tumor immune environment is unclear.
17p vikoch 27-06-2024 2 1 Download
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Ebook "Arthritis research: Methods and protocols (Second edition)" expands upon the first edition to present new and current techniques for the research of arthritis and related conditions. A compendium of leaders in the field contribute chapters that cover practical research methods such as the intravital multiphoton microscopy technique, techniques for evaluating exhausted CD8 T cell and for studying nucleic acid sensors and their effects,...
215p dongmelo 27-05-2024 3 2 Download
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The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor mutational burden (TMB) may also dictate response, and some oncogenes (i.e., WNT/β-catenin) are known to mediate immunosuppression.
19p vibransone 28-03-2024 3 2 Download
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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p vicwell 29-02-2024 3 1 Download
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Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated. Forty-one fresh lung adenocarcinoma (ADC) tissues were analyzed using flow cytometry for comprehensive immunoprotein. Formalin-fixed tissues were immunostained for hexokinase-2 (HK2) to assess cancer cell glycolysis.
11p vileonardodavinci 23-12-2023 6 3 Download
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The distribution of tissue-inflating lymphocytes has been shown to affect the prognosis of patients with pancreatic cancer in some previous studies. However, the role of peripheral lymphocytes in pancreatic cancer remains debated. The purpose of this study was to analyze the peripheral subtypes of T lymphocytes, and establish their association with the prognosis of patients with pancreatic cancer.
14p vileonardodavinci 23-12-2023 9 3 Download
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Hepatocellular carcinoma (HCC) is a major health concern, necessitating a deeper understanding of its prognosis and underlying mechanisms. This study aimed to investigate the mechanism and prognostic value of CD8+T Cell exhaustion (CD8+TEX)-related genes in HCC and construct a survival prognosis prediction model for patients with HCC.
15p vileonardodavinci 23-12-2023 3 3 Download
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Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. As a novel approach, we wanted to assess patient survival influenced by combined presence of mutations and densities of CD8+ cytotoxic T cells.
10p vialfrednobel 23-12-2023 4 3 Download
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Selective activation of Delta-like 1 (DLL1)-Notch signaling is a new approach to activate CD8+ T cell and suppress tumor growth, while the efficacy remains modest. Lentinan (LNT) is a clinically used immunomodulation agent. Thus, we hypothesized that LNT could improve the efficacy of DLL1.
11p vialfrednobel 23-12-2023 4 3 Download
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Previous assessments of peritumoral infammatory infltrate in colorectal cancer (CRC) have focused on the role of CD8+ T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators of active immune cell function, specifically granzyme B (GZMB) and CD68 in the tumour microenvironment.
13p vialfrednobel 23-12-2023 4 3 Download
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Bệnh bạch cầu tế bào lympho T lớn có hạt (T-Cell Large Granular Lymphocytic Leukemia – T-LGLL) là một phân nhóm trong u lympho tế bào T/NK trưởng thành. T-LGLL được đặc trưng bởi sự tăng sinh đơn dòng của các tế bào lympho lớn có hạt trong máu ngoại biên kéo dài >6 tháng.
6p vibranson 06-12-2023 8 3 Download
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The scavenger receptor CD36 was reported to be highly expressed on tumor-infiltrating CD8+ T cells, but the clinical role remains obscure. This study aims to explore the infiltration and clinical value of CD36+CD8+ T cells in NSCLC.
13p vischultz 20-10-2023 2 1 Download
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Part 2 book "Vaccine adjuvants and delivery systems" includes content: New ISCOMs meet unsettled vaccine demands, liposomal cytokines and liposomes targeted to co stimulatory molecules as adjuvants for HIV subunit vaccines, archaeosome vaccine adjuvants for cross priming CD8 T-Cell immunity, mucosal adjuvants and delivery systems, cytokines as vaccine adjuvants,... and other contents.
268p oursky05 20-09-2023 4 1 Download
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Major histocompatibility complex (MHC) class I glycoproteins present selected peptides or antigens to CD8+T cells that control the cytotoxic immune response. The MHC class I genes are among the most polymorphic loci in the vertebrate genome, with more than twenty thousand alleles known in humans.
14p vihagrid 30-01-2023 5 3 Download