Chemokine responses
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Immune checkpoint blockade (ICB) therapy has demonstrated considerable clinical benefit in several malignancies, but has shown favorable response in only a small proportion of cancer patients. Recent studies have shown that matrix metalloproteinases (MMPs) are highly associated with the microenvironment of tumors and immune cells. However, it is unknown whether MMPs are involved in immunotherapy.
19p vibransone 28-03-2024 5 2 Download
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C–C chemokine receptor type 7 (CCR7) participates in chemotactic and metastatic responses in various cancers, including in esophageal squamous cell carcinoma (ESCC). The microRNA (miRNA) let-7a suppresses migration and invasion of various types of cancer cells by downregulating CCR7 expression.
9p vileonardodavinci 23-12-2023 4 3 Download
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CXC chemokine ligand 3 (CXCL3) is a member of CXC-type chemokine family that is identified as a major regulator in immune and inflammation responses. Recently, numerous evidence indicated that CXCL3 is broadly expressed in various human tumor types, and it is also known to play a critical role in mediating tumor development and progression.
12p vileonardodavinci 23-12-2023 2 2 Download
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The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Notch signaling mutation for responding to immunotherapy in CRC.
12p vialfrednobel 23-12-2023 4 3 Download
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Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fibroblasts, angiogenesis, metastasis, and growth.
17p vikolindagrabar 27-07-2022 1 1 Download
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Sepsis is a critical challenge for the older adults as the immune function is less responsive by aging. Although cell numbers seem preserved in the older adults, macrophages present age-related function decline, which including reduced chemokines, phagocytosis, and autophagy.
11p viisaacnewton 25-04-2022 7 4 Download
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Coccidiosis is an infectious disease with large negative impact on the poultry industry worldwide. It is an enteric infection caused by unicellular Apicomplexan parasites of the genus Eimeria. The present study aimed to gain more knowledge about interactions between parasites and the host immune system during the early asexual replication phase of E. tenella in chicken caeca.
19p vitzuyu2711 29-09-2021 11 1 Download
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The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines.
12p viseulgi2711 31-08-2021 8 1 Download
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Infection with Toxoplasma gondii is thought to damage the brain and be a risk factor for neurological and psychotic disorders. The immune response-participating chemokine system has recently been considered vital for brain cell signaling and neural functioning.
14p visilicon2711 20-08-2021 12 1 Download
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Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, which is known to enable CRC metastasis, as well as the cancer-initiating cell marker and peptidase CD26, which terminates activity of its chemokine CXCL12.
14p vimoscow2711 29-08-2020 5 1 Download
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There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding strongly supports the use of cancer vaccine strategies.
9p vibaku2711 22-07-2020 5 0 Download
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Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response.
9p vikuala271 13-06-2020 9 1 Download
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Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people.
10p viwashington2711 04-12-2019 11 0 Download
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The genetic markers in inflammatory responses during mastitis afford a reasonable way for improving milk production in the Egyptian buffalo breed. Among them is the interleukin 8 Receptor Gene (IL8RB) (CXCR2); a chemokine receptor gene augments the neutrophil migration during infection. To understand its role better during mastitis in Egyptian buffalos, twenty-five dairy animals representing the normal, sub-clinically, clinically and chronically affected buffalos were randomly selected from different districts.
9p trinhthamhodang1 14-11-2019 17 2 Download
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This manual applies equally to conventionally housed birds and free-range operations. It is recognised that free-range birds will have some exposure to wild birds. However, in these environments measures should be taken to minimise the congregation of waterfowl and the impacts of wild birds generally, and these measures should be documented. While footbaths are not appropriate for a free range paddock, a system should be implemented to monitor and prevent any potential hazardous organic material or litter entering free range paddocks and these measures should be documented.
36p loginnhanh 22-04-2013 44 2 Download
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At the national level, the US Bureau of Economic Analysis (BEA) produces updated national I-O tables and multipliers every five years. At a sub-national level, the IMPLAN model and the RIMS-II model are the two models which are most commonly used to estimate these impacts. RIMS was used for the Wisconsin study, while IMPLAN was used for the California study and was also a component of the broader TREDIS system used for the California and Chicago studies. Custom state-specific I-O models developed at universities were used for the Oklahoma and Georgia studies. ...
26p trinhcaidat 19-04-2013 48 3 Download
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Predicting Needs as a Buyer. It is difficult to describe precisely the level of resources required to run an ex- periment or job. Depending on the inputs to a program, the ideal level of resource consumption can vary dramat- ically. Moreover, there is a tangible penalty formisestimating resource need, since these bids are made in advance of when the resources will actually be available. In order to match enough buyers with sellers, current market-based resource allocation schemes batch allocations into blocks of time.
8p nhacsihuytuan 06-04-2013 53 6 Download
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These names, as is the mark of auteurship, stand for something more than the films they have signed (The Marriage of Maria Braun, Lili Marleen, Aguirre, Kaspar Hauser, Kings of the Road, The American Friend, Hitler-A Film from Germany, The Patriot, The Tin Drum, The German Sisters, Heimat, Germany Pale Mother).
8p khanhchilam 01-04-2013 45 6 Download
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The 2001 White Paper "European Transport Policy for 2010: Time to Decide" sets out the ambitious target of reducing the number of road fatalities with 50 percent by 2010. This requires a rapid increase in the efforts of all safety stakeholders. To support these actions, the European Commission officially launched the eSafety initiative in April 2002.
389p nhacnenzingme 23-03-2013 57 4 Download
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States have largely abdicated regulatory authority for electronic media—television and radio—even though a review of federal pre- emption law suggests that only transmissions into a state from out of state or on cable are preempted. In other words, broadcasts that originate within a state are subject to state regulation. Although a state may claim such jurisdiction without a provision that makes the authority explicit, an explicit statement of jurisdiction is substantially preferable.
13p nhacchovina 22-03-2013 63 5 Download