Connexin 43
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Germ cell tumors are relatively common in young men. They derive from a non-invasive precursor, called germ cell neoplasia in situ, but the exact pathogenesis is still unknown. Thus, further understanding provides the basis for diagnostics, prognostics and therapy and is therefore paramount.
20p vischultz 20-10-2023 4 1 Download
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To examine the levels of exosome-derived connexin 43 (Cx43) in plasma and estimate its forecast value in patients with melanoma. Methods We measured the plasma exosome-derived Cx43 levels in the plasma of 112 melanoma patients and 50 healthy controls.
8p vischultz 20-10-2023 2 1 Download
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Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermiainduced gap junction (GJ) remodelling is closely linked to RA.
8p vampires36 30-12-2021 8 0 Download
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Astrocyte Connexin 43 (Cx43) is essential for the trophic and protective support of neurons during brain ischemia reperfusion (I/R) injury. It is believed that dexmedetomidine participates in Cx43-mediated effects. However, its mechanisms remained unclear. This study aims to address the relationship and regulation among them.
12p vidietmarhopp 28-12-2021 10 0 Download
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Nghiên cứu này nhằm hiểu rõ hơn sự biểu hiện gen Connexin 43 ở mức độ mRNA trong phức hợp cumulus-oocyte (COC) ở heo theo giai đoạn phát triển của nang noãn, theo giai đoạn nuôi cấy thành thục phức hợp tế bào trứng để làm cơ sở cho các nghiên cứu biểu hiện gen liên quan đến chất lượng tế bào trứng nhằm nâng cao hiệu quả hệ thống nuôi cấy. Mời các bạn cùng tham khảo!
5p quakhumetmoi 12-09-2021 25 1 Download
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Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by hindlimb suspension (HLS), an animal model of skeletal unloading.
8p viannito2711 20-04-2021 8 2 Download
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Previous studies demonstrated an important role for connexin 43 (Cx43) in the regulation of apoptosis by influencing mitochondrial functions. This study aimed to investigate the relationship between Cx43 and lipopolysaccharide (LPS)-induced oxidative stress and apoptosis in human umbilical vein endothelial cells (HUVECs).
10p vimaine2711 26-03-2021 8 1 Download
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We studied the relationships among Cx43, CD105, and VEGF in specimens of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) with different serum AFP levels with respect to recurrence and metastasis.
9p vijennie2711 29-09-2020 23 1 Download
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Treatment failure is a critical issue in breast cancer and identifying useful interventions that optimize current cancer therapies remains a critical unmet need. Expression and functional studies have identified connexins (Cxs), a family of gap junction proteins, as potential tumor suppressors. Studies suggest that Cx43 has a role in breast cancer cell proliferation, differentiation, and migration.
13p vialabama2711 21-09-2020 7 0 Download
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Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of GPR64 has not been studied in endometrial cancer. Our objective is to investigate the role of GPR64 in endometrial cancer.
10p vikuala271 13-06-2020 10 0 Download
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Cardiomyocyte under hypoxia cause cell death or damage is associated with heart failure. Gap junction, such as connexin 43 play a role in regulation of heart function under hypoxia. Caffeic acid phenethyl ester (CAPE) has been reported as an active component of propolis, has antioxidative, anti-inflammatory antiproliferative and antineoplastic biological properties.
5p viwashington2711 04-12-2019 12 1 Download
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Upregulation of connexin 43 (Cx43) showed potential in enhancing immune surveillance that was suppressed in the tumor microenvironment. The expression of indoleamine 2, 3-dioxygenase (IDO) is one of the crucial factors contributing to tumor immune tolerance by depletion of tryptophan and IDO-mediated tryptophan metabolites.
8p vicaracas2711 27-11-2019 11 1 Download
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Morphine is the most effective drugs for attenuating various types of severe pain, but morphine abuse carries a high risk of systemic fibrosis. Our previous have indicated that systemic administration of morphine hinders angiogenesis and delays wound healing. Here we have explained the pathological mechanism underlying the effect of morphine on wound healing.
8p vihasaki2711 12-11-2019 17 0 Download
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Astragalus membranaceus has been shown to possess anti-inflammation and antitumor properties. Several studies have indicated that extracts of Astragalus membranaceus (PG2) have growth inhibitory effects on tumor.
9p vinasaki2711 12-11-2019 7 0 Download
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Chemotherapy is now in common use for the treatment of tumors; however, with tumor growth retardation comes the severe side effects that occur after a chemotherapy cycle.
8p vinasaki2711 12-11-2019 11 0 Download
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Polarized membrane sorting of connexin 43 (Cx43) has not been well-char-acterized. Based on the presence of a putative sorting signal, YKLV(286– 289), within its C-terminal cytoplasmic domain, we hypothesized that Cx43 is selectively expressed on the basolateral surface of Madin–Darby canine kidney (MDCK) cells in a tyrosine-dependent manner.
14p viettel02 20-02-2013 30 2 Download
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Proteoliposomes were directly prepared by synthesizing membrane proteins with the use of minimal protein synthesis factors isolated fromEscherichia coli(the PURE system) in the presence of liposomes. Connexin-43 (Cx43), which is a water-insoluble integral membrane protein that forms a hexa-meric complex in membranes, was cotranslationally integrated with an essentially uniform orientation in liposomes.
10p viettel02 19-02-2013 32 2 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of ischemic preconditioning on ischemia/ reperfusion-induced arrhythmias by upregulatation of connexin 43 expression...
6p thulanh23 21-11-2011 48 3 Download