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Cytotoxic evaluation
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In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.
7p
dianmotminh02
03-05-2024
4
1
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Zoanthid is a potential natural resource with many biological activities, such as antioxidant, antiviral, antiinflammatory, and cytotoxic activity. Therefore, this study aimed to evaluate the antioxidant activity of 70% ethanol crude extract and dichloromethane fraction from Zoanthus vietnamensis. The total polyphenol content of ethanol and dichloromethane extracts were 19.36 ± 1.37 and 24.95 ± 0.63 mg GAE/g extract, respectively.
9p
dianmotminh02
03-05-2024
4
1
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In this work, a new sulfated polysaccharide was isolated from green seaweed Caulerpa racemosa harvested at Nha Trang sea. The structure of obtained polysaccharide was determined and its cytotoxic activity was evaluated. The results showed that structure of the polysaccharide has a main chain of (1→4)-β-D-galactopyranose residues and branches are (1→3)-α-L-glucopyranose-2,4-disulfate residues linked to the main chain at C-6 position.
6p
dianmotminh02
03-05-2024
2
1
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natural fiber for the construction of hybrid bio-composites. In the current research project, a thorough analysis of the use of soy-PF resin for the creation of composites reinforced with jute was conducted. A novel and practical cutlery material was created after the mechanical properties were evaluated and optimized. In order to study the value addition of these newly proposed biocomposite materials as an ecological alternative in terms of natural resources versus synthetic resources, variables such as hardness, cytotoxicity, and degrading qualities of composites were also explored.
9p
dianmotminh02
03-05-2024
3
2
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This study was conducted to determine the solvent and additives to obtain high bioactive compounds from Daklak Vietnam Robusta GCB to evaluate extraction methods, the properties (emulsion formation, particle, stability) and testing the antioxidant, antibiotic and cytotoxicity of the nanoemulsions of Robusta GCB extract.
7p
viellison
28-03-2024
2
1
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Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with cytotoxic chemotherapy are highly effective in the treatment of advanced non–small-cell lung cancer (NSCLC) with EGFR mutations. The purpose of this study is to evaluate the efcacy and safety of this combination in advanced NSCLC patients with an EGFR/TP53 co-mutation.
12p
vileonardodavinci
23-12-2023
2
2
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In the last few decades, pyrazoline-based substances have emerged as potential antimicrobial and anticancer candidates. In concern with antimicrobial activity, this study aims to build a docking model to predict the structure of potential 2-pyrazoline derivatives. The cytotoxicity of some compounds was also evaluated to get insight into the structure–anticancer activity relationship of the 2- pyrazoline derivatives.
8p
vikissinger
21-12-2023
2
1
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Less than half of unselected metastatic cancer patients benefit from the immune checkpoint inhibitor (ICI) therapy. Systemic cancer-related inflammation may influence the efficacy of ICIs and thus, systemic inflammatory markers could have prognostic and/or predictive potential in ICI therapy.
11p
vileonardodavinci
23-12-2023
4
2
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In this study, nine ferulic and caffeic acid-based 1,2,4 and 1,3,4 oxadiazole molecular hybrids were synthesized and their cytotoxic activity was evaluated mainly against Glioblastoma (GBM) cell lines. Compounds 1 and 5 exhibited the highest inhibitory activity against three different GBM cell lines (LN229, T98G, and U87), without toxicity to healthy human mesenchymal stem cells (hMSC). In addition, their cytotoxicity was also evaluated against three additional cancer cell lines and more inhibitory results were found than GBM cell lines.
22p
lyhuyenthu
31-01-2023
6
2
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In this study, anticholinergic, antidiabetic, antioxidant and cytotoxic activities of Reseda lutea L. (R. lutea) were determined. Ethanol extracts of R. lutea (EERL) and water extract of R. lutea (WERL) were prepared for biochemical analysis. The antioxidant capacities of EERL and WERL were evaluated with 6 different methods. In addition, acetylcholinesterase (AChE), α-amylase and α-glycosidase enzyme inhibition by EERL were measured.
16p
lyhuyenthu
31-01-2023
3
2
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SEM and TEM were used to evaluate the surface morphology and microstructure of the fiber membrane. Ultraviolet spectrophotometry was used to detect drug release. A LIVE/DEAD Viability/Cytotoxicity Kit and fluorescence staining were used to detect cell morphology and activity. Alkaline phosphatase and calcium mineralization deposition were used to evaluate the osteoinductive activity of the scaffold. Dynamic mechanical analysis was used to determine the Young’s modulus, maximum load, and maximum elongation of the prepared scaffold.
12p
lyhuyenthu
31-01-2023
6
2
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Multi-walled carbon nanotube (MWCNT) is one of the most momentous carbonaceous nanoparticles which is widely used for various applications such as electronics, vehicles, and therapeutics. However, their possible toxicity and adverse effects convert them into a major health threat for humans and animals.
10p
vihagrid
30-01-2023
7
3
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The acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of BC were studied. Cytotoxicity of BC was evaluated in cultured C3A hepatoma cells (HepG2/C3A) using a lactate dehydrogenase (LDH) activity assay. Acute toxicity was tested in adults Wistar rats treated with a single dose of BC.
5p
vihermione
06-01-2023
13
3
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A heteropolysaccharide was isolated by cold aqueous extraction from edible mushroom Pleurotus eryngii (“King Oyster”) basidiocarps and its biological properties were evaluated. Structural assignments were carried out using mono- and bidimensional NMR spectroscopy, monosaccharide composition, and methylation analyses.
10p
vihermione
06-01-2023
13
2
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The aim of the present study was to purify the crude pectin extract obtained from gabiroba pulp, elucidate its chemical structure, and evaluate the antitumor potential of crude and purified pectin in a human glioblastoma model.
9p
vihermione
06-01-2023
6
2
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Surfactants have been used as a tool to improve the properties of polymeric nanoparticles (NPs) and to increase the rate of hydrophobic drug release by means of these nanoparticles. In this context, this study evaluated the effect of lecithin on the characteristics of chitosan (CHI) and chondroitin sulfate (CS) nanoparticles, when applied in curcumin (Curc) release.
10p
vihermione
06-01-2023
10
2
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Marine fungi are evaluated as a potential source for new natural compounds with bioactivities of pharmaceutical values. In this study, 66 fungal strains, isolated from 37 sponge samples in Nha Trang bay, were determined for cytotoxic activity against two human cancer cell lines, including cervical cancer (Hela) and breast cancer (MCF-7) cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
7p
vipagani
24-10-2022
4
2
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Chalcones are a class of compounds with a wide range of biological activities. In addition, derivatives based on the quinazolinone skeleton are currently of interest to research in the screening of compounds with cytotoxic effects. Compounds containing chalcone structures on the basis of quinazolinone can yield new structures with cytotoxic effects.
8p
viporsche
25-10-2022
6
2
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The 2-benzoylbenzoxazole derivatives were known for their significant biological activities such as antiproliferative activity, inhibition of FAAH enzyme (fatty acid amide hydrolase). In this study, we report a simple and efficient method for the synthesis of such compounds by the direct reaction of o-aminophenol with acetophenone catalyzed by sulfur in DMSO.
8p
vimclaren
12-10-2022
7
2
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Platinum-based chemoradiotherapy is the standard treatment for unresectable stage III non-small-cell lung cancer (NSCLC). However, few studies have evaluated the efficacy of subsequent chemotherapy for relapsed NSCLC following platinum-based chemoradiotherapy.
10p
vikolindagrabar
27-07-2022
3
1
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