Domains of variables

The thesis "Stability of some classes of degenerate two-phase difference systems with delay" is to study the stability of degenerate two-phase systems with mixed delay in the direction of variation; Stability and dissipation in finite domain of degenerate 2-D system with variable delay; Evaluation of the gain set and control design for a degenerate 2-D system in the Roesser model with variable delay;... Please refer to it!

120p gaupanda019 21-03-2024 5 1   Download

Protein phosphatase 2A (PP2A) is an abundant heterotri-meric serine/threonine phosphatase containing highly con-served structural (A) and catalytic (C) subunits. Its diverse functions in the cell are determined by its association with a highly variable regulatory and targeting B subunit. At least three distinct gene families encoding B subunits are known: B/B55/CDC55, B¢/B56/RTS1 and B¢¢/PR72/130. No homologyhasbeen identi®edamong theBfamilies, and little is knownabout howtheseBsubunits interactwith the PP2A A and C subunits....

7p research12 23-04-2013 29 3   Download

The new antigen receptor (IgNAR) from sharks is a disul-phide bonded dimer of two protein chains,each containing one variable and five constant domains,and functions as an antibody. In order to assess the antigen-binding capabilities of isolated IgNAR variable domains (VNAR),we have con-structed anin vitro library incorporating synthetic CDR3 regions of 15–18 residues in length.

12p tumor12 20-04-2013 26 3   Download

This study describes the construction of a library of single-chain antibody fragments (scFvs) from a single human donor by individual amplification of all heavy and light variable domains (1.1·10 8 recombinants). The lib-rary was panned using the phage display technique, which allowed selection of specific scFvs (3F and C1) capable of recognizing Cn2, the major toxic component of Centruroides noxiusscorpion venom.

11p awards 06-04-2013 50 4   Download

The double-stranded RNA-binding motif (dsRBM) is anabbbafold with a well-characterized function to bind structured RNA molecules. This motif is widely distributed in eukaryotic proteins, as well as in proteins from bac-teria and viruses. dsRBM-containing proteins are involved in processes ran-ging from RNA editing to protein phosphorylation in translational control and contain a variable number of dsRBM domains.

0p awards 06-04-2013 30 4   Download

Superantigens (SAgs) are a class of disease-causing and immunostimulatory proteins of bacterial or viral origin that activate a large number of T-cells through interaction with the Vbdomain of T-cell receptors (TCRs). In this study, recombinant TCRbchains were constructed with human variable domains Vb5.2, Vb1and Vb2.1, expressed as inclusion bodies, refolded and purified. The Streptococcus pyogenesSAg SSA-1 was cloned and expressed as a soluble periplasmicprotein. SSA-1wasobtainedbothas amonomer and a dimer that has an intermolecular disulfide bond. ...

9p awards 05-04-2013 37 5   Download

Intracellularly expressed antibodies (intrabodies) have been used to inhibit the function of various kinds of protein inside cells. However, problems with stability and functional expression of intrabodies in the cytosol remain unsolved. In this study, we show that single-chain variable fragment (scFv) intrabodies constructed with a heavy chain variable (VH) leader signal sequence at the N-terminus were translocated from the endoplasmic reti-culum into the cytosol of T lymphocytes and inhibited the function of the target molecule, Wiskott–Aldrich syndrome protein (WASP)....

14p dell39 27-03-2013 38 5   Download

G-protein-coupled receptor kinases (GRK) are known to phosphorylate agonist-occupied G-protein-coupled receptors. We expressed and function-ally characterized mouse GRK6 proteins encoded by four distinct mRNAs generated by alternative RNA splicing from a single gene, mGRK6-A to mGRK6-D.

13p dell39 27-03-2013 41 4   Download

Recurrent missense fibroblast growth factor receptor 3 (FGFR3) mutations have been ascribed to skeletal dysplasias of variable severity including the lethal neonatal thanatophoric dysplasia types I (TDI) and II (TDII). To elucidate the role of activating mutations causing TDI on receptor traffick-ing and endocytosis, a series of four mutants located in different domains of the receptor were generated and transiently expressed.

11p galaxyss3 19-03-2013 36 4   Download

Vertebrate metallothioneins are found to contain Zn(II) and variable amounts of Cu(I),in vivo, and are believed to be important for d 10 -metal control. To date, structural information is available for the Zn(II) and Cd(II) forms, but not for the Cu(I) or mixed metal forms. Cu(I) binding to metallothionein-1 has been investigated by circular dichroism, luminescence and 1 H NMR using two synthetic fragments representing thea- and the b-domain.

14p galaxyss3 19-03-2013 34 5   Download

Domains within the multienzyme polyketide synthases are linked by non-catalytic sequences of variable length and unknown function. Recently, the crystal structure was reported of a portion of the linker between the acyl-transferase (AT) and ketoreductase (KR) domains from module 1 of the erythromycin synthase (6-deoxyerythronolide B synthase), as a pseudo-dimer with the adjacent ketoreductase (KR).

14p galaxyss3 19-03-2013 34 4   Download

Small heat shock proteins (sHsps) are intracellular molecular chaperones that prevent the aggregation and precipitation of partially folded and destabilized proteins. sHsps comprise an evolutionarily conserved region of 80–100 amino acids, denoted thea-crystallin domain, which is flanked by regions of variable sequence and length: the N-terminal domain and the C-terminal extension.

14p vinaphone15 28-02-2013 34 2   Download

Introduction The purpose of this paper is to prove optimal estimates for solutions of the Kohn-Laplacian for certain classes of model domains in several complex variables. This will be achieved by applying a type of singular integral operator whose novel features (related to product theory and flag kernels) differ essentially from the

66p noel_noel 17-01-2013 55 7   Download

A basic result in the theory of holomorphic functions of several complex variables is the following special case of the work of H. Cartan on the sheaf cohomology on Stein domains ([10], or see [14] or [16] for more modern treatments). Theorem 1.1. If V is an analytic variety in a domain of holomorphy Ω and if f is a holomorphic function on V , then there is a holomorphic function g in Ω such that g = f on V . The subject of this paper concerns an add-on to the structure considered in Theorem 1.1 which...

25p tuanloccuoi 04-01-2013 51 5   Download

The antigen-binding site of immunoglobulins is formed by six regions, three from the light and three from the heavy chain variable domains, which, on association of the two chains, form the conventional antigen-binding site of the antibody.

9p cosis54 04-01-2013 45 5   Download

ON WEAK SOLUTIONS OF THE EQUATIONS OF MOTION OF A VISCOELASTIC MEDIUM WITH VARIABLE BOUNDARY V. G. ZVYAGIN AND V. P. ORLOV Received 2 September 2005 The regularized system of equations for one model of a viscoelastic medium with memory along trajectories of the field of velocities is under consideration. The case of a changing domain is studied. We investigate the weak solvability of an initial boundary value problem for this system. 1. Introduction The purpose of the present paper is an extension of the result of [21] on the case of a changing domain. Let Ωt ∈ Rn , 2 ≤...

31p sting12 10-03-2012 43 6   Download

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: The C-terminal variable domain of LigB from Leptospira mediates binding to fibronectin

12p hoami_238 17-09-2011 44 3   Download