EGFR mutations

Xem 1-12 trên 12 kết quả EGFR mutations

Summary of Biology doctoral thesis: Study on mutations, expression of EGFR and methylation of related genes in lung adenocarcinoma patients

Analysis of mutation and protein expression of EGFR in patients with lung adenocarcinoma; investigation the hypermethylation frequency of EGFR, BRCA1, MGMT, MLH1, RASSF1A and correlation of the methylation between these genes with mutations and protein expression of EGFR.

27p capheviahe26 25-01-2021 19 4 Download

Summary of Doctoral thesis in Medicine: Studying the mRNA expression of CIZ1b, VEGF genes and egfr mutations with merkel cell virus infection in patients with non- small cell lung cancer

Assessed the level of mRNA expression of CIZ1b, VEGF, EGFR mutations and the rate of Merkel cell infection in patients with non-small cell lung cancer. Assessed the level of mRNA expression of CIZ1b, VEGF, EGFR mutations and the rate of Merkel cell infection in patients with non-small cell lung cancer.

32p trinhthamhodang7 31-08-2020 35 3 Download

Summary of Biology Doctoral thesis: Study on mutation, protein expression of egfr and methylation of related genes in lung adenocarcinoma patients

Analysis of mutation and protein expression of EGFR in patients with lung adenocarcinoma. Investigation the hypermethylation frequency of EGFR, BRCA1, MGMT, MLH1, RASSF1A and correlation of the methylation between these genes with mutations and protein expression of EGFR.

27p trinhthamhodang7 31-08-2020 36 2 Download
Summary of Phd thesis: Clinical, subclinical features and resistance to tyrosine kinase inhibitor of lung cancer patients with EGFR mutations

To describe the clinical and subclinical features of lung cancer patients with EGFR mutations before TKIs therapy and in the relapsed period. To identify the T790M mutation and MET amplification in patients with lung cancer and EGFR-TKIs resistance and the relationship with clinical and subclinical features.

29p cothumenhmong6 17-07-2020 14 2 Download
Báo cáo khoa học: The impact of the regulatory design on the response of epidermal growth factor receptor-mediated signal transduction towards oncogenic mutations

Epidermal growth factor receptor (EGFR)-mediated signal transduction is often hyperactivated in tumour cells and therefore considered a promising target for cancer therapy. A number of computational models have been developed which describe the pathway in great detail.

13p media19 04-03-2013 40 3 Download
Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression

Controlled activation of epidermal growth factor receptor (EGFR) is sys-tematically guaranteed at the molecular level; however, aberrant activation of EGFR is frequently found in cancer. Transcription induced by EGFR activation often involves the coordinated expression of genes that positively and negatively regulate the original signaling pathway; therefore, altera-tions in EGFR kinase activity may reflect changes in gene expression asso-ciated with the pathway.

13p vinaphone15 25-02-2013 34 5 Download
Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors

The function of the epidermal growth factor receptor (EGFR) is dysregu-lated in various types of malignancy as a result of gene amplification, mutations, or abnormally increased ligand production. Therefore, the tyro-sine kinase activity of the EGFR is a promising therapeutic target.

11p mobifone23 18-01-2013 44 3 Download
Báo cáo hóa học: " Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer

8p dauphong4 03-01-2012 57 6 Download
báo cáo khoa học: " Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC

7p toshiba22 21-11-2011 83 6 Download
Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer

Abstract Epidermal growth factor receptor (EGFR) kinase domain mutations hyperactivate the kinase and confer kinase addiction of the non-small-cell lung cancer (NSCLC) tumor cells. Almost all of these mutations are located within exons 18-21. The -216 single nucleotide polymorphism in the promoter region is associated with increased EGFR production. We present a method for detecting these common mutations in 81 cases of NSCLC.

6p toshiba23 18-11-2011 71 2 Download
Báo cáo khoa học: "Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma

10p matuot_238 12-10-2011 41 3 Download
Ras Mutation/ColorectalCancer

Trong vài năm qua, sự chữa trị trong oncology đã càng ngày càng đi sâu vào molocular biology. Trên thế giới, hiện nay đã bắt đầu có thuốc chống ung thư dựa theo lối này, chẳng hạn monoclonal antibodies chống lại epidermal growth factor receptor (EGFR) và vascular endothelial epidermal growth factor (VGEF). Tại HKỳ các thuốc này đang được dùng trong chiến tuyến thứ nhì hay thứ ba (second line or third line therapies) để chống ung thư đã chuyển di (metastatic colorectal carcinoma). Trong việc tạo sinh ra ung thư ruột già đã chuyển di, ở tầm...

4p sinhtobo111 13-04-2011 38 3 Download