Expression evaluation
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Resveratrol has demonstrated its ability to regulate BRCA1 gene expression in breast cancer cells, and previous studies have established the binding of MBD proteins to BRCA1 gene promoter regions. The aimed to evaluate the impact of MBD proteins on the regulation of BRCA1, BRCA2, and p16 genes and their consequential effects on breast cancer cells.
18p vishanshan 27-06-2024 2 1 Download
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CD13 (APN) is an Alanyl-Aminopeptidase with diverse functions. The role of CD13 for gliomas is still unknown. In this study, data of glioma patients obtained by TCGA and CGGA databases were used to evaluate the survival rate and prognostic value of CD13 expression level. Protein expression of CD13 was confirmed by immunofluorescence staining of fresh patient tissues.
15p vishanshan 27-06-2024 1 1 Download
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Chondroitin sulfate proteoglycan 4 pseudogene 12 (CSPG4P12) has been implicated in the pathogenesis of various cancers. This study aimed to evaluate the association of the CSPG4P12 polymorphism with esophageal squamous cell carcinoma (ESCA) risk and to explore the biological impact of CSPG4P12 expression on ESCA cell behavior.
10p vikoch 27-06-2024 2 1 Download
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Carcinoma of unknown primary origin (CUP) is a metastatic carcinoma in which the primary tumor remains elusive even after evaluation of the clinical history, physical examination, radiological findings, laboratory tests and other diagnostic investigations.
12p vikoch 27-06-2024 2 1 Download
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T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid leukemia (AML) cells and it is related to AML progression. As, Glutamine appears to play a prominent role in malignant tumor progression, especially in their myeloid group, therefore, in this study we aimed to evaluate the relation between TIM-3/Galectin-9 axis and glutamine metabolism in two types of AML cell lines, HL-60 and THP-1.
15p vikoch 27-06-2024 4 1 Download
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Gastric cancer (GC) remains a predominant form of malignant tumor globally, necessitating innovative nonsurgical therapeutic approaches. This investigation aimed to delineate the expression landscape of macrophageassociated genes in GC and to evaluate their prognostic significance and influence on immunotherapeutic responsiveness.
17p vikoch 27-06-2024 1 1 Download
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. In this study, an investigation was conducted to evaluate the expression of genes encoding SOS1, HKT1, HAK10, and NHX1 transporters in the leaf and root tissues of two contrasting rice cultivars, salt tolerant DP and salt sensitive IR28, under salt stress of 150 mM NaCl by RT-qPCR approach. RT-qPCR data revealed that the expression of HKT1, HAK10, SOS1, and NXH1 were upregulated at a higher level in the DP cultivar than in the IR28 cultivar in response to salt stress treatment.
9p dianmotminh02 03-05-2024 4 1 Download
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The research carried out a critical analysis of existing labor potential assessment methodologies at the regional level, which allowed taking into account the identified deficiencies offer the author's approach to express diagnostics, which does not require a special wide survey, allows to get objective results and it is the basis for identifying the most important problems and priority ways of solving them. The essence of the approach is to conduct regional clustering procedure on the level of the state of the labor potential on the basis of the author's indicator system.
8p longtimenosee09 08-04-2024 3 1 Download
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There are many evidences showing the fact that some hard conditions from environment, namely abiotic stress, could make several significantly negative impacts on crop production. However, some plant species can overcome these bad situations by complicated mechanisms. This study has shown the result of the construction the recombinant vector carrying CodA gene which could encode an enzyme, named choline oxidase, and is controlled by Rd29A promoter.
8p vilarry 01-04-2024 5 1 Download
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Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are the primary biomarkers evaluated for clinical management of cancer patients across histologies.
18p vibransone 28-03-2024 6 1 Download
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The study identifies the effect of the implementation of information and communication technology-driven digital supply chain (ICT-DSC) model in education institutes. Besides that, the study defines the integration and evaluation criteria of the Digital Supply Chain model in the academic industry. Finally, an integrated model for educational institutes in Bangladesh is developed through the study. This ICT application-based DSC model would formulate a requirement roadmap to express a guideline for the educational technology impact.
7p longtimenosee07 29-03-2024 3 2 Download
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Ebook "The role of degenerate states in chemistry (Advances in chemical physics, Volume 124)" provides a forum for critical, authoritative evaluations in every area of the discipline. In a format that encourages the expression of individual points of view, experts in the field present comprehensive analyses of subjects of interest. Volume 124 collects innovative papers on "Complex States of Simple Molecular Systems," "Electron Nuclear Dynamics," "Conical Intersections and the Spin-Orbit Interaction," and many more related topics.
812p coduathanh1122 27-03-2024 1 1 Download
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The deregulation of microRNA-140 (miRNA-140) has been reported to be involved in the human pathogenesis of Osteoarthritis (OA). However, in Vietnam, to our knowledge, there is a limited study of evaluation of a miRNA-140 expression. The commercial kits for the quantitation of miRNA-140 are more expensive.
7p vibego 02-02-2024 2 0 Download
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Mesothelin (MSLN) is a cell-surface glycoprotein found in various solid tumours. Cancer therapies targeting MSLN have been developed in recent years; however, the available information on MSLN expression in cervical cancer is limited. This study aimed to evaluate MSLN expression in various histological types of cervical cancer and examine its relationship with prognosis.
9p vileonardodavinci 23-12-2023 3 2 Download
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The aim of this study is to explore the expression and clinical relevance of CAF-associated markers, EZH2 and FOXM1 in gastric samples. Protein expression were detected and evaluated by multi-plex immunofuorescence (mIF) in 93 cases of gastric cancer (GC) and 31 cases of gastric intraepithelial neoplasia (GIN). The correlation among their expression, and the relationship of them with clinicopathological parameters and prognosis in GC were then analyzed.
14p vileonardodavinci 23-12-2023 5 3 Download
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Several studies showed that lack of CD56 expression was a poor prognostic factor for patients with newly diagnosed multiple myeloma (NDMM). However, other studies were not able to confirm the prognostic value of CD56 in NDMM. This study aimed to evaluate the prognostic value of CD56 expression for patients with NDMM who received autologous stem cell transplantation (ASCT).
9p vileonardodavinci 23-12-2023 3 2 Download
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Many cytogenetic changes and gene mutations are associated with acute myeloid leukemia (AML) survival outcomes. CD56 is related to poor prognosis when expressed in adult AML patients. However, the prognostic value of CD56 in children with AML has rarely been reported. In this research, we aimed to evaluate the prognostic value of CD56 in childhood AML.
9p vileonardodavinci 23-12-2023 5 2 Download
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The increasing prevalence of cancer detection necessitated practical strategies to deliver highly accurate, beneficial, and dependable processed information together with experimental results. We deleted the cancer biomarker NOX4 using three novel genetic knockout (KO) methods. Homology-directed repair (HDR), Dual allele HITI (Du-HITI) and CRISPR-excision were utilized in this study.
15p vileonardodavinci 23-12-2023 5 3 Download
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Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosis of HNSCC has been questioned and remains unclear.
13p vileonardodavinci 23-12-2023 7 3 Download
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Mantle cell lymphoma (MCL) has remained incurable in most patients. The expression of PD-L1 as a prognostic and predictive marker has not been fully evaluated in MCL. The current study aimed to determine PD-1/ PD-L1 expression in MCL specimens and its significance as an immune check point inhibitor.
8p vileonardodavinci 23-12-2023 5 4 Download