Glutathione transferases

In this study, we determined the in vitro inhibitory effects of metal ions such as Cu2+, Cd2+, Ag+, and Co2+ on GST enzyme activity. For this aim, GST was purified from C. tarichi Pallas liver with 37.36% yield and 29.304 EU/mg specific activity using the chromatographic method. The Vmax values of liver GST were determined for CDNB and GSH to be 1.245 and 0.562 EU/mL, respectively, and the Km values were found 0.89 and 0.06 mM, respectively, using the Lineweaver–Burk plot.

8p lyhuyenthu 31-01-2023 3 2   Download

Bài viết "Nghiên cứu chức năng của Botrytis Susceptible1 Interactor (BOI) trong điều khiển sự ra hoa ở cây Arabidopsis" cho thấy BOI tương tác đặc hiệu với HDA6 nhưng không tương tác với glutathion-S-transferase (GST). Kết quả này gợi ý BOI có thể ức chế FT thông qua HDAC. Cần có các nghiên cứu sâu hơn để chứng minh mối liên hệ giữa BOI và HADC trong ức chế sự biểu hiện của FT ở cây Arabidopsis. Mời các bạn cùng tham khảo chi tiết bài viết tại đây!

5p phuong62310 31-01-2023 7 2   Download

Glutathione S-transferases (GSTs) have been reported to regulate the plant tolerance to environmental stresses. Many plant GSTs exhibited the roles on promoting tolerance to drought stress, oxidative stress and plant hormones.

10p vihagrid 30-01-2023 11 3   Download

Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxifcation of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine kinase inhibitors.

11p viangelamerkel 27-07-2022 4 2   Download

Glutathione-S transferases (GSTs) comprise a series of critical enzymes involved in detoxification of endogenous or xenobiotic compounds. Among several GSTs, Glutathione S-transferases mu (GSTM) has been implicated in a number of cancer types. However, the prognostic value and potential functions of the GSTM family genes have not been investigated in lung adenocarcinoma (LUAD).

13p visusanwojcicki 28-06-2022 9 2   Download

The disturbance in the carbohydrate level was expressed by impairment in the activity of carbohydrate enzymes in treated 2nd and 4th instar larvae. In both treated instar larvae there was a significant increase in the enzyme activity of alpha and beta esterase as well as in glutathione S-transferase.

6p schindler 30-12-2021 11 0   Download

Anti-oxidative stress characters of extract was evaluated in liver and kidney antioxidant enzyme activities; catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase and glutathione peroxidase which were magnified in parallel with remarkable elevation on glutathione concentration comparable with diabetic control.

13p schindler 30-12-2021 9 0   Download

The results indicated that enzyme activity was varied according to the exposure time, concentration and type of heavy metals. CAT activity increased significantly beginning at day 45 of HMs exposure.

6p meyerowitz 25-12-2021 11 0   Download

The fine-tuned regulation of the Halliwell–Asada cycle (ascorbate–glutathione pathway) in Arabidopsis thaliana under boron (B) toxicity was shown in our previous report. In this study, we investigated the expression levels of some members of the glutathione S-transferase (GST) superfamily, such as phi (GSTF2, GSTF6, GSTF7, and GSTF8), tau (GSTU19), and zeta (GSTZ1) classes in Arabidopsis thaliana that were exposed to 1 mM boric acid (1B) and 3 mM boric acid (3B).

9p tudichquannguyet 29-11-2021 14 1   Download

The aim of the present study was to determine the effect of high temperature stress (HT) and to evaluate the protective role of fungicide pretreatment against HT stress in tomato leaves. The oxidative stress was triggered under HT stress through an increase in the content of malondialdehyde (MDA) and hydrogen peroxide (H2O2). Also, it caused a decline in photosynthetic pigments and enhanced the proline in tomato. However, the activities of catalase (CAT; EC 1.11.1.6), peroxidase (POX; EC 1.11.1.7), and glutathione S-transferase (GST; EC.2.5.1.

14p tudichquannguyet 29-11-2021 6 1   Download

The common deletion of the glutathione S-transferase Mu 1 (GSTM1) gene in humans has been shown to be involved in xenobiotic metabolism and associated with bladder cancer. However, the evolution of this deletion has not been investigated.

12p vibeauty 23-10-2021 7 1   Download

Mục tiêu của đề tài là đánh giá sự tích tụ KLN (Cu, Pb, Zn và Cd) trong mang, gan, thận của cá chép và cá rô phi theo mùa và theo mặt cắt trong khu vực nghiên cứu; phân tích sự biến động của nồng độ protein và hoạt tính GST trong cùng mẫu cá phân tích kim loại nặng; bước đầu xác định tương quan giữa nồng độ kim loại nặng tích tụ với nồng độ protein và hoạt tính GST trong cùng mẫu cá phân tích.

82p closefriend03 13-10-2021 23 5   Download

Đề tài đánh giá sự tích tụ KLN (Cu, Pb, Zn và Cd) trong mang, gan, thận của cá chép và cá rô phi theo mùa và theo mặt cắt trong khu vực nghiên cứu. Phân tích sự biến động của nồng độ protein và hoạt tính GST trong cùng mẫu cá phân tích kim loại nặng. Bước đầu xác định tương quan giữa nồng độ kim loại nặng tích tụ với nồng độ protein và hoạt tính GST trong cùng mẫu cá phân tích

8p closefriend03 13-10-2021 24 1   Download

Glutathione transferases (GSTs), the ancient, ubiquitous and multi-functional proteins, play significant roles in development, metabolism as well as abiotic and biotic stress responses in plants. Wheat is one of the most important crops, but the functions of GST genes in wheat were less studied.

15p viansan2711 30-07-2021 7 1   Download

Mutation breeding is an extraordinary tool in plant breeding to increase the genetic variability, where mutations in anthocyanin biosynthesis are targets to generate distinctive phenotypes in ornamental species.

16p vilichoo2711 23-06-2021 18 1   Download

Glutathione S-transferases (GSTs) represent a ubiquitous gene family encoding detoxification enzymes able to recognize reactive electrophilic xenobiotic molecules as well as compounds of endogenous origin.

15p vijichea2711 28-05-2021 10 1   Download

Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy.

9p vimontana2711 05-04-2021 9 1   Download

Glutathione S-transferase P1 (GSTP1) has been reported to function as a tumor suppressor gene in various types of human cancers. Aberrant methylation of tumor-related genes at the promoter regions can inactivate genes, which is important in the carcinogenesis of breast cancer.

8p vimoscow2711 29-08-2020 4 0   Download

Robust and precise molecular prognostic predictors for luminal breast cancer are required. This study aimed to identify key methylation sites in luminal breast cancer, as well as precise molecular tools for predicting prognosis.

13p vibaku2711 22-07-2020 9 1   Download

We conducted a meta-analysis to evaluate the relationship between the glutathione S-transferase μ1 (GSTM1)– and glutathione S-transferase θ1 (GSTT1)– null genotypes and susceptibility to bladder cancer.

16p vimanila2711 25-06-2020 6 0   Download