Human skin

This study investigated the in vitro effects of ZnO NP and chemical UV filters commonly used sunscreens on the function of immortalised and primary skin cells. ZnO particulates (30 nm, 80 nm and 200 nm) were compared to the chemical UV filters: butylmethoxydibenzoylmethane (BMDBM) ethylhexylmethoxycinnamate (EHMC), ethylhexylsalicylate (EHS), homomenthylsalicylate (HMS) and 4-methylbenzylidenecamphor (MBC). Human epidermal keratinocytes (NHEK), epidermal melanocytes (NHEM), dermal fibroblasts (NHDF) and the immortalised keratinocyte HaCaT cell line were used in this study.

324p runthenight05 01-03-2023 11 3   Download

Therehas longbeenconjectureover thedegree towhichthere may be structural and functional heterogeneity in the tetra-mericserineproteasetryptase(EC 3.4.21.59), amajor mediator of allergic inflammation. We have applied 2D gel electrophoresis to analyze the extent, nature, and variability of thisheterogeneity inlysatesofmast cells isolatedfromlung and skin, and in preparations of purified tryptase. Gels were silver stained, or the proteins transferred to nitrocellulose blots and probed with either tryptase-specific monoclonal antibodies or various lectins. ...

14p tumor12 20-04-2013 39 3   Download

Malassezia sympodialisis an opportunistic yeast that col-onizes human skin and may induce IgE and T cell reac-tivity in patients with atopic eczema/dermatitis syndrome (AEDS). Previously, we have cloned and expressed six recombinant allergens (rMala s 1 and rMala s 5 to rMal-a s 9) from this yeast. By combining high throughput screening and phage surface display techniques, 27 com-plete and partial IgE-binding clones of M. sympodialis have been identified. Here we enlarged the panel of recombinant M.

10p dell39 03-04-2013 40 3   Download

Anovel photoprotectivemycosporinewas isolated fromthe lichenized ascomyceteCollema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially pre-vented pyrimidine dimer formation and completely preven-ted UV-B induced erythema when applied to the skin prior to irradiation....

5p dell39 03-04-2013 42 4   Download

Waardenburg syndrome (WS) is an auditory–pigmentary disorder that exhibits varying combinations of sensorineural hearing loss and abnormal pigmentation of the hair and skin. WS type 4 (WS4), a subtype of WS, is characterized by the presence of the aganglionic megacolon and is associ-

16p inspiron33 26-03-2013 33 5   Download

In recent years, possible health hazards due to radiofrequency radiation (RFR) emitted by mobile phones have been investigated. Because several publications have suggested that RFR is stressful, we explored the potential biological effects of Global System for Mobile phone communication at 900 MHz (GSM-900) exposure on cultures of isolated human skin cells and human reconstructed epidermis (hRE) using human keratinocytes.

17p inspiron33 23-03-2013 52 3   Download

Prolidase is a Mn 2+ -dependent dipeptidase that cleaves imidodipeptides containing C-terminal proline or hydroxyproline. In humans, a lack of prolidase activity causes prolidase deficiency, a rare autosomal recessive disease, characterized by a wide range of clinical outcomes, including severe skin lesions, mental retardation, and infections of the respiratory tract.

13p inspiron33 23-03-2013 45 4   Download

Transglutaminase 1 (TGase 1) is an essential enzyme for cornified enve-lope formation in stratified squamous epithelia. This enzyme catalyzes the cross-linking of glutamine and lysine residues in structural proteins in differentiating keratinocytes. To gain insight into the preferred substrate structure of TGase 1, we used a phage-displayed random peptide library to screen primary amino acid sequences that are preferentially selected by human TGase 1.

11p vinaphone15 28-02-2013 32 2   Download

Papillomaviruses are epitheliotropic non-enveloped double-stranded DNA viruses, whose replication is strictly dependent on the terminally differenti-ating tissue of the epidermis. They induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy (e.g. cervical carci-noma). Prior to entry into basal cells, virions attach to heparan sulfate moieties of the basement membrane.

11p viettel02 20-02-2013 39 3   Download

The eosinophil cationic protein⁄RNase 3 and the skin-derived RNase 7 are two human antimicrobial RNases involved in host innate immunity. Both belong to the RNase A superfamily and share a high cationicity and a common structural architecture.

13p mobifone23 18-01-2013 38 3   Download

One of the greatest challenges to confront an artist is drawing the human figure. Our bodies are infinitely complex yet intimately familiar, giving rise to a subject that is difficult to depict accurately yet judged incessantly. The human figure is almost overwhelmingly complex for the artist to draw. The human figure is an organic structure that defies geometric simplification. It is composed of bones, muscles, and organs, all of which are covered by a flexible layer of skin. The body has many moving parts that make it almost impossible to define as a shape. Within its skeleton are more...

16p audi123 31-07-2010 179 29   Download

Sea lion characteristics: Webbed flipper-like forefoot and hind foot. Front flipper thicker on front edge. Skin of flipper extends past tips of toe bones, supported by individual cartilages attached to ends of toe bones. Noticeable claws on three middle toes of hind foot; other claws tiny and inconspicuous. Front flipper triangular; hind flipper rectangular. Hind limb can be advanced forward—can walk, but thigh and lower leg encased in skin of abdomen (seals can't walk—their hind limbs permanently extended backward). Elbow also enclosed in body skin, but forearms are free.

12p audi123 31-07-2010 224 7   Download