Improved variants

The reader may wonder why the amplifier stages studied in previous chapters are not suited to high-power applications. Suppose we wish to deliver 1 W to an 8- speaker. Approximating the signal with a sinusoid of peak amplitude VP, we express the power absorbed by the speaker as:

82p vanmanh1008 23-05-2013 49 7   Download

The need for operating circuits at increasingly higher speeds has always challenged designers. From radar and television systems in the 1940s to gigahertz microprocessors today, the demand for pushing circuits to higher frequencies has required a solid understanding of their speed limitations. In this chapter, we study the effects that limit the speed of transistors and circuits, identifying topologies that better lend themselves to high-frequency operation.

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The thesis studied the development and implementation of the conceptual Continuous Improvement Teamworking (CIT) Model for strategic performance improvement in retail banking operations. The investigation using of a dominant qualitative to a Less-dominant quantitative approach as a mixed-method strategy revealed the importance of the CIT Model realised through the CTIO (Concern-Task-Interaction-Outcome) Problem-Solving Cycle. The CTIO Cycle is a variant form of the traditional Deming-Shewhart PDCA (Plan-Do-Check-Action) Cycle.

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Precision medicine promises to improve both the efficacy and safety of therapeutic products by better informing why some patients respond well to a drug, and some experience adverse reactions, while others do not. Pharmacogenomics is a key component of precision medicine and can be utilized to select optimal doses for patients, more precisely identify individuals who will respond to a treatment and avoid serious drug-related toxicities.

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Feedback is an integral part of our lives. Try touching your fingertips with your eyes closed; you may not succeed the first time because you have broken a feedback loop that ordinarily “regulates” your motions. The regulatory role of feedback manifests itself in biological, mechanical, and electronic systems, allowing precise realization of “functions.” For example, an amplifier targeting a precise gain of 2.00 is designed much more easily with feedback than without.

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In two cycles of an error-prone PCR process, variants of formate dehy-drogenase from Candida boidiniiwere created which revealed an up to 4.4-fold (440%) higher residual activity after entrapment in polyacrylamide gels than the wild-type enzyme. These were identified in an assay using sin-gle precursor molecules of polyacrylamide instead of the complete gel for selection.

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l-Asparaginase (EC 3.5.1.1,l-ASNase) catalyses the hydrolysis ofl-Asn, producingl-Asp and ammonia. This enzyme is an anti-neoplastic agent; it is used extensively in the chemotherapy of acute lymphoblastic leukaemia. In this study, we describe the use of in vitro directed evolution to create a new enzyme variant with improved thermal stability.

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Locus Reference Genomic sequences: an improved basis for describing human DNA variants

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA...

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