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Janus kinase
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Primary myelofibrosis [PMF] is a myeloproliferative neoplasm associated with reduced overall survival (OS). Management strategies for PMF have evolved over the last two decades, including approval of ruxolitinib as the first Janus kinase 1 (JAK1)/JAK2 inhibitor for patients with intermediate or high-risk myelofibrosis. This study assessed changes in mortality before and after ruxolitinib approval, independent of ruxolitinib treatment.
8p
vileonardodavinci
23-12-2023
3
2
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Nghiên cứu nhằm mô tả kết quả điều trị của Ruxolitinib và các phương pháp điều trị kinh điển trong quản lý bệnh xơ tủy nguyên phát tại Bệnh viện Truyền máu Huyết học. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hàng loạt ca, hồi cứu hồ sơ của bệnh nhân xơ tủy nguyên phát được điều trị tại BV.TMHH từ năm 2011 đến tháng 8/2022.
9p
vibranson
06-12-2023
6
2
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Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Tofacitinib is a Janus kinase inhibitor that is useful in the treatment of disorders such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
4p
videadpool
05-05-2023
5
2
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Musculoskeletal manifestations are common extraintestinal manifestations of inflammatory bowel disease. Tofacitinib is a Janus kinase inhibitor approved for treating rheumatoid arthritis and ulcerative colitis. There are limited data on the efficacy of tofacitinib in managing inflammatory bowel disease-associated arthritis.
6p
videadpool
05-05-2023
3
2
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Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that can be characterised by a somatic mutation (JAK2V617F). This mutation causes the bone marrow to produce excessive blood cells and is found in polycythaemia vera (~95%), essential thrombocythaemia and primary myelofibrosis (both ~50%).
12p
vinarcissa
21-03-2023
2
1
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Myeloproliferative neoplasm is a group of blood cancers, including three main diseases: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera. Several molecular signaling pathways such as JAK/STAT, PI3K or SHP have been demonstrated that play a crucial role in controlling the signaling-mediated immune response related to Myeloproliferative neoplasms.
6p
vimelindagates
18-07-2022
4
2
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The generation of induced pluripotent stem cells (iPSCs) has underdefined mechanisms. In addition, leukemia inhibitory factor (LIF) activated Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway is the master regulator for naïve-state pluripotency achievement and maintenance. However, the regulatory process to attain naïve pluripotent iPSCs is not well understood.
17p
vibeauty
23-10-2021
11
0
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Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint destruction, disability, and decreased quality of life (QOL). Inhibition of Janus kinase (JAK) signaling ameliorates articular inflammation and joint destruction in animal models of RA, but its effects on behaviors indicating well-being are poorly understood.
8p
vioregon2711
22-02-2021
6
2
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We systematically reviewed the effectiveness of intensive treatment strategies in achieving remission in patients with both early and established Rheumatoid Arthritis (RA). Methods: A systematic literature review and meta-analysis evaluated trials and comparative studies reporting remission in RA patients treated intensively with disease modifying anti-rheumatic drugs (DMARDs), biologics and Janus Kinase (JAK) inhibitors.
14p
vitennessee2711
01-02-2021
15
1
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Combination therapy, which reduces the dosage intensity of the individual drugs while increasing their efficacy, is not a novel approach for the treatment of cancer. Methylsulfonylmethane (MSM) is an organic sulfur compound shown to act against tumor cells. Tamoxifen is a commercially available therapeutic agent for breast malignancies.
16p
viamsterdam
18-09-2020
9
1
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Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear.
12p
vikuala271
13-06-2020
8
1
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In a follow up study we tested a higher concentration (0.1%) of PR022 HOCl gel in comparison to the Janus kinase inhibitor tofacitinib, both of which are currently in clinical phase studies for treatment of human atopic dermatitis.
8p
vimax2711
30-03-2020
14
1
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Zebrafish (Danio rerio) are an attractive vertebrate model for the molecular dissection of disease mechanisms. Janus kinase (JAK)/signal transducer and activator of transcription (stat) has been defined through studies of cytokine signaling pathways in mammals.
6p
vicaracas2711
27-11-2019
16
1
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Calmodulin (CaM) is phosphorylated in vitro and in vivo by multiple protein-serine/threonine and protein-tyrosine kinases. Casein kinase II and myosin light-chain kinase are two of the well established protein-serine/threonine kinases implicated in this process. On the other hand, within the protein-tyrosine kinases involved in the phosphorylation of CaM are receptors with tyrosine kinase activity, such as the insulin receptor and the epidermal growth factor receptor, and nonreceptor protein-tyrosine kinases, such as several members of the Src family kinases, Janus kinase 2, and p38Syk....
13p
research12
01-06-2013
43
4
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The leptin receptor (LEPR) is a class I cytokine receptor signalling via both the janus kinase⁄signal transducer and activator of transcription (JAK⁄STAT) and the MAP kinase pathways. In addition, leptin has been shown previously to activate AMP-activated kinase (AMPK) in skeletal muscle. To enable a detailed analysis of leptin signalling in pancreatic beta cells, LEPR point mutants with single or combined exchanges of the three intracellular tyrosines were expressed in HIT-T15 insulinoma cells....
11p
awards
05-04-2013
31
2
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SOCS3 is a negative regulator of cytokine signalling that inhibits Janus kinase-signal transduction and activator of transcription (JAK-STAT) mediated signal tranduction by binding to phosphorylated tyrosine residues on intracellular subunits of various cytokine receptors, as well as possibly the JAK proteins.
11p
dell39
27-03-2013
37
4
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The suppressors of cytokine signalling (SOCS) proteins inhibit cytokine signalling by direct interaction with Janus kinases (JAKs) or activated cytokine receptors. In addition to the N-ter-minal and SH2 domains that mediate these interactions, SOCS proteins contain a C-terminal SOCS box. Evidence suggests SOCS box-containing proteins act as part of an elongin-cullin-SOCS (ECS) E3 ubiquitin ligase complex, marking target pro-teins for degradation.
35p
inspiron33
26-03-2013
55
5
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Type I interferons (IFN) are important components of the innate antiviral response. A key signalling pathway activated by IFNais the Janus kinase⁄ signal transducer and activator of transcription (JAK⁄STAT) pathway. Major components of the pathway have been identified. However, critical kinetic properties that facilitate accelerated initiation of intracellular antiviral signalling and thereby promote virus elimination remain to be determined.
14p
viettel02
19-02-2013
36
2
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The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is utilized by a range of cytokines (interferons, IL-2 and IL-6 amongst others) that control survival, proliferation and differentiation responses in diverse cell types. The realisation that unregulated activation of this pathway is a key driver of not only chronic inflammatory diseases such as rheumatoid arthritis, colitis and psoriasis, but also many cancers has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals.
788p
yeutinh98
22-09-2012
61
7
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The Janus kinases (Jaks)...
6p
thulanh19
09-11-2011
44
1
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