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Mediator complex
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YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.
18p
vishanshan
27-06-2024
1
1
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Ovarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all gynecological cancers. Glycosylation is a specific post-translational modification that plays an important role in tumor progression, immune escape and metastatic spread. The aim of this work was to identify the major glycosylation-related genes (GRGs) in OC and construct an effective GRGs signature to predict prognosis and immunotherapy.
16p
vikoch
27-06-2024
1
1
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Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor.
1368p
vimeyers
29-05-2024
5
2
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Ebook "Free-radical synthesis and functionalization of heterocycles" describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups.
356p
tracanhphuonghoa1007
22-04-2024
4
2
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The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.
10p
vibransone
28-03-2024
6
2
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Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis.
17p
vibransone
28-03-2024
3
2
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The genetic origins of chemotherapy resistance are well established; however, the role of epigenetics in drug resistance is less well understood. To investigate mechanisms of drug resistance, we performed systematic genetic, epigenetic, and transcriptomic analyses of an alkylating agent-sensitive murine lymphoma cell line and a series of resistant lines derived by drug dose escalation.
11p
vioraclene
31-03-2024
2
1
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Human resource and Technology are the important assets of the organization. For this reason, the purpose of the present study was to examine the impact of advanced Manufacturing technology, human capital and employee empowerment on supply chain performance, furthermore, the mediating role of organizational innovation is examined as well. The data is collected from the employees of manufacturing firms in Indonesia in the form of questionnaire. The response rate of the current study is 63.4 percent.
8p
longtimenosee06
27-03-2024
3
2
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Ebook "Stereoselective syntheses of tetrahydropyrans: Applications to the synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A" describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A.
198p
tudohanhtau1006
29-03-2024
2
1
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Ebook "Late transition metal-carboryne complexes: Synthesis, structure, bonding, and reaction with alkenes and alkynes" shows in this thesis that transition metals can mediate or catalyze the cycloaddition or coupling reactions of carboryne with alkynes or alkenes to afford benzocarboranes, alkenylcarboranes or dihydrobenzocarboranes. These results represent powerful strategies to assemble useful complex molecules from very simple precursors in a single operation. Carboranes have many applications in medicine.
143p
coduathanh1122
27-03-2024
5
1
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Common and rare variants contribute to the etiology of complex traits. However, the extent to which the phenotypic effects of common and rare variants involve shared molecular mediators remains poorly understood. The question is essential to the basic and translational goals of the science of genomics, with critical basic-science, methodological, and clinical consequences.
13p
vicwell
29-02-2024
4
2
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Ebook "Nitrosyl complexes in inorganic chemistry, biochemistry and medicine II" has not only had implications for biology but also homogeneous catalysis and Professor Heinz Berke and Dr. Yangfeng Jiang have reviewed recent developments in this field in the chapter entitled “Nitrosyl Complexes in Homogeneous Catalysis.” The ability of nitric oxide to coordinate in a flexible fashion has considerable implications for lowering the kinetic barriers of reactions of organic molecules at metal centres and Berke and Jiang give many examples of this charactristic.
266p
nhanphanguyet
28-01-2024
7
3
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Obesity is a high-risk factor for development and poor prognosis of triple-negative breast cancer (TNBC), which was considered as a high malignant and poor clinical outcome breast cancer subtype. TNBC proliferation and migration regulated by obesity is complex.
10p
vialfrednobel
23-12-2023
3
3
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Ebook "Polymer science: A comprehensive reference - Volume 3: Chain polymerization of vinyl monomers" presents the great progress achieved in precise synthetic polymerization techniques for vinyl monomers to control macromolecular architecture: the development of metallocene and post-metallocene catalysis for olefin polymerization, new ionic polymerization procedures, and atom transfer radical polymerization, nitroxide mediated polymerization, and reversible addition-fragmentation chain transfer systems as the most often used controlled/living radical polymerization methods.
978p
loivantrinh
29-10-2023
4
2
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Major advances in genotyping technology have generated high-density maps of single nucleotide polymorphism (SNP) markers that provide an unprecedented opportunity to identify genes underlying complex traits. Several family-based statistical methods showing robust population stratification have been developed to test the association between multiple markers and disease-susceptibility genes.
6p
vinarcissa
21-03-2023
2
1
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In the Mediterranean fruit fly (medfly), Ceratitis capitata, a highly invasive agricultural pest species, polyandry, associated with sperm precedence, is a recurrent behaviour in the wild. The absence of tools for the unambiguous discrimination between competing sperm from different males in the complex female reproductive tract has strongly limited the understanding of mechanisms controlling sperm dynamics and use.
8p
vinarcissa
21-03-2023
3
1
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Gene expression is potentially an important heritable quantitative trait that mediates between genetic variation and higher-level complex phenotypes through time and condition-dependent regulatory interactions.
13p
vihagrid
30-01-2023
5
3
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In this research, well-dispersed zero-valent copper nanoparticles (CuNPs) were successfully synthesized from a welldefined complex of [Cu(OH)(TMEDA)]2Cl2 in neat glycerol via a polyol method, under microwave irradiation (MW) assistance.
3p
vichristinelagarde
04-07-2022
7
1
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Preeclampsia remains a significant obstetric risk worldwide. The pathophysiology of preeclampsia is complex, with multiple stages involving maladaptations in both placental and maternal physiology. The placenta links the preclinical stage of impaired remodeling of the uterine vasculature, occurring in early pregnancy, to the later clinical stagesm characterised by the maternal syndrome of hypertension and proteinuria.
10p
ngoccthanh
30-06-2022
10
6
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Plant adaptive responses to changing environments involve complex molecular interplays between intrinsic and external signals. Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on plant development, their influence on chromatin-based transcriptional controls remains poorly explored.
16p
vialfrednobel
29-01-2022
18
0
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