Báo cáo khoa học: Structural model for an AxxxG-mediated dimer of surfactant-associated protein C
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The pulmonary surfactant prevents alveolar collapse and is required for normal pulmonary function. One of the important components of the surfactant besides phos-pholipids is surfactant-associated protein C (SP-C). SP-C shows complex oligomerization behavior and a transition to b-amyloid-like fibril structures, which are not yet fully understood. Besides this nonspecific oligomerization, MS and chemical cross-linking data combined with CD spectra provide evidence of a specific, mainlya-helical, dimer at lowto neutral pH....
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