Metabolism disorder
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In patients with end-stage chronic kidney failure, there are a number of disorders that cause bone damage. In particular, secondary hyperparathyroidism (SHPT) is related to chronic kidney failure, a calcium-phosphorus metabolism disorder that causes bone disorder.
6p viengfa 23-10-2024 1 0 Download
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Wilson’s disease (WD) is a rare inherited copper metabolism disorder with many clinical symptoms highlighted by hepatic and cerebral features. We present the case of a 17 - year - old female patient with generalized tonic - clonic seizures and cerebellar ataxia who presented to our hospital.
4p vinatisu 29-08-2024 2 1 Download
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Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age. Insulin resistance appears to be a critical factor in PCOS pathogenesis. Metformin, an insulin-sensitizing agent, is thus the preferred treatment option for PCOS.
8p vinatisu 29-08-2024 3 1 Download
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Magnesium (Mg)-deficiency is one of the most prevalent physiological disorders causing a reduction in Citrus yield and quality. ‘Xuegan’ (Citrus sinensis) seedlings were irrigated for 16 weeks with nutrient solution containing 2 mM (Mg-sufficiency) or 0 mM (Mg-deficiency) Mg(NO3)2.
20p vishikamaru2711 29-04-2020 21 1 Download
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Wilson disease (WD), an inherited disorder affecting copper metabolism, is characterized by hepatic cirrhosis and neuronal degeneration, which result from toxic levels of copper that accumulate in the liver and brain, respectively. We reported previously that the 1.3-kb promoter of the WD gene contains four metal response elements (MREs). Among the four MREs, MREa plays the most important role in the transcriptional activation of the WD promoter.
11p research12 01-06-2013 53 3 Download
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Insulin is the principal regulatory hormone involved in the tight regulation of fuel metabolism. In response to blood glucose levels, it is secreted by the b cells of the pancreas and exerts its effects by binding to cell surface receptors that are present on virtually all cell types and tissues. In humans, perturbations in insulin function and/or secretion lead to diabetes mellitus, a severe disorder primarily characterized by an inability to maintain blood glucose homeostasis. Furthermore, it is estimated that 90–95% of diabetic patients exhibit resistance to insulin action....
10p research12 01-06-2013 34 4 Download
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Obesity is a central feature of the metabolic syndrome and is associated with increased risk for insulin resistance and type II diabetes. Here, we investigated the contribution of human apoliprotein E3 and mouse apoli-protein E to the development of diet-induced obesity in response to western-type diet. Our data show that apolipoprotein E contributes to the development of obesity and other related metabolic disorders, and that human apolipoprotein E3 is more potent than mouse apolipoprotein E in promoting obesity in response to western-type diet. ...
14p research12 29-04-2013 45 3 Download
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Misfolded proteins, aggregates, and inclusion bodies are hall-marks of the cytopathology of neurodegenerative disorders including Huntington’s disease, Amyotropic lateral sclerosis, Parkinson’s disease, Prion diseases, and Alzheimer’s disease. The appearance of proteins with altered folded states is regula-ted by the protein folding quality control machinery and age-dependent. We have identified an unexpected molecular link between metabolic state, accumulation of damaged proteins, the heat-shock response and chaperones, and longevity....
61p fptmusic 11-04-2013 43 4 Download
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Human tyrosine aminotransferase (hTATase) is the pyridoxal phosphate-dependent enzyme that catalyzes the reversible transamination of tyrosine to p-hydrophenylpyruvate, an important step in tyrosine metabolism. hTATase deficiency is implicated in the rare metabolic disorder, tyrosine-mia type II.
10p inspiron33 26-03-2013 51 4 Download
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Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by multifarious dysfunctional alterations including mitochon-drial impairment. In the present study, the formation of inclusions caused by the mutation of huntingtin protein and its relationship with changes in energy metabolism and with pathological alterations were investigated both in transgenic and 3-nitropropionic acid-treated mouse models for HD.
16p inspiron33 23-03-2013 38 6 Download
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Farnesoid X receptor (FXR), a member of the nuclear receptor superfam-ily, has been shown to play pivotal roles in bile acid homeostasis by regu-lating the biosynthesis, conjugation, secretion and absorption of bile acids. Accumulating data suggest that FXR signaling is involved in the pathogen-esis of liver and metabolic disorders.
14p vinaphone15 27-02-2013 28 3 Download
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High-throughput metabolomics is a dynamically developing technology that enables the mass separation of complex mixtures at very high resolu-tion. Metabolic profiling has begun to be widely used in clinical research to study the molecular mechanisms of complex cell disorders.
11p viettel02 22-02-2013 33 4 Download
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Obesity and its associated disorders, including diabetes and cardiovascular disease, have now reached epidemic proportions in the Western world, resulting in dramatic increases in healthcare costs. Understanding the pro-cesses and metabolic perturbations that contribute to the expansion of adi-pose depots accompanying obesity is central to the development of appropriate therapeutic strategies.
9p viettel02 20-02-2013 64 4 Download
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Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magnetic resonance spectroscopy was used to evaluate regional metabolic alterations, following a 24-hour hypoxic or hyperoxic exposure on the background of ischemic brain insult, in two
9p toshiba23 18-11-2011 47 2 Download
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Tiểu đường là một bệnh biến dưỡng (metabolic disorder) khiến đường lên cao trong máu, làm khổ triệu triệu người trên thế giới. Trong 100 người chúng ta, có 1 người bị tiểu đường (1%). Về lâu về dài, bệnh gây những biến chứng quan trọng ở mắt, thận, thần kinh và mạch máu. Tiểu đường có 2 loại: loại 1 xảy ra sớm, trước tuổi 40, do thiếu chất “insulin” trong cơ thể, loại 2 xảy ra muộn hơn, sau tuổi 40, do các tế bào không sử dụng được chất “insulin”, dù “insulin” có sẵn đấy (“insulin”...
7p buddy7 29-06-2011 80 3 Download
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Có 5 loại : 1. Nhiễm toan chuyển hóa (metabolic acidosis) (ví dụ ngừng tim). 2. Nhiễm toan hô hấp (respiratory acidosis) (ví dụ bệnh phổi tắc mãn tính với ứ đọng CO2). 3. Nhiễm kiềm chuyển hóa (metabolic alkolosis) (ví dụ mửa kéo dài) 4. Nhiễm kiềm hô hấp (respiratory acidosis) (ví dụ hội chứng tăng thông khí). 5. Rối loạn axít-kiềm hỗn hợp (nghĩa là nhiễm kiềm hô hấp và nhiễm toan chuyển hóa, như được thấy nơi một người trưởng thành với ngộ độc salicylate ; nhiễm toan chuyển hóa với bù hô hấp). ...
16p thiuyen111 11-04-2011 82 9 Download
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Clinical Manifestations Intestinal Disorders Food Poisoning C. perfringens, primarily type A, is the second or third most common cause of food poisoning in the United States (Chap. 122). The responsible toxin is thought to be a cytotoxin produced by 75% of strains isolated from cases of foodborne disease. The cytotoxin binds to a receptor on the small-bowel brush border and induces a calcium ion–dependent alteration in permeability. The associated loss of ions alters intracellular metabolism, resulting in cell death.
7p colgate_colgate 21-12-2010 68 5 Download
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Metabolic and Inflammatory Disorders Acute febrile illnesses may result in vascular damage. This can result from immune complexes containing viral antigens or the viruses themselves. Certain pathogens, such as the rickettsiae causing Rocky Mountain spotted fever, replicate in endothelial cells and damage them. Vascular purpura may occur in patients with polyclonal gammopathies but more commonly in those with monoclonal gammopathies, including Waldenstrom's macroglobulinemia, multiple myeloma, and cryoglobulinemia.
5p thanhongan 07-12-2010 67 3 Download
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Harrison's Internal Medicine Chapter 100. Megaloblastic Anemias Megaloblastic Anemias: Introduction The megaloblastic anemias are a group of disorders characterized by the presence of distinctive morphologic appearances of the developing red cells in the bone marrow. The cause is usually deficiency of either cobalamin (vitamin B 12) or folate, but megaloblastic anemia may arise because of genetic or acquired abnormalities affecting the metabolism of these vitamins or because of defects in DNA synthesis not related to cobalamin or folate (Table 100-1).
5p thanhongan 07-12-2010 61 4 Download
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Harrison's Internal Medicine Chapter 97. Paraneoplastic Neurologic Syndromes Paraneoplastic Neurologic Syndromes: Introduction Paraneoplastic neurologic disorders (PNDs) are cancer-related syndromes that can affect any part of the nervous system (Table 97-1). They are remote effects of cancer, caused by mechanisms other than metastasis or by any of the complications of cancer such as coagulopathy, stroke, metabolic and nutritional conditions, infections, and side effects of cancer therapy. In 60% of patients the neurologic symptoms precede the cancer diagnosis.
5p thanhongan 07-12-2010 84 4 Download