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Mitochondrial oxidative metabolism
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Part 2 book "Marks' basic medical biochemistry - A clinical approach" includes content: Basic concepts in the regulation of fuel metabolism by insulin; glucagon, and other hormones, cellular bioenergetics - adenosine triphosphate and O2; digestion, absorption, and transport of carbohydrates; generation of adenosine triphosphate from glucose, fructose, and galactose - glycolysis; tricarboxylic acid cycle; oxidative phosphorylation and mitochondrial function; oxygen toxicity and free radical injury; formation and degradation of glycogen.... and other contents.
366p
oursky07
24-10-2023
3
2
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Part 2 book "Netter’s essential biochemistry" includes content: Pentose phosphate pathway, oxidative stress, and glucose; phosphate dehydrogenase de ciency; citric acid cycle and thiamine de ciency; oxidative phosphorylation and mitochondrial diseases; glycogen metabolism and glycogen storage diseases; gluconeogenesis and fasting hypoglycemia; fatty acids, ketone bodies, and ketoacidosis; triglycerides and hypertriglyceridemia
259p
oursky03
21-08-2023
8
2
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The switch from oxidative phosphorylation to glycolysis in proliferating cancer cells, even under aerobic conditions, has been shown first in 1926 by Otto Warburg. Today this phenomenon is known as the “Warburg effect” and recognized as a hallmark of cancer.
9p
vinarcissa
21-03-2023
6
1
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This study aimed to estimate the effect of three concentrations (75 µg/mL, 150 µg/mL and 300 µg/mL) of the European raspberry (Rubus iadeus) on the selected quality parameters of bovine spermatozoa after 0h, 2h, and 24h of in vitro culture. Sperm motility was evaluated using the Computer-assisted sperm analysis (CASA) system. The mitochondrial activity was detected by the metabolic (MTT) assay.
6p
mudbound
10-12-2021
11
0
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Many cancer cells exhibit reduced mitochondrial respiration as part of metabolic reprogramming to support tumor growth. Mitochondrial localization of several protein tyrosine kinases is linked to this characteristic metabolic shift in solid tumors, but remains largely unknown in blood cancer.
14p
viamsterdam
18-09-2020
17
1
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Apoptosis-inducing factor (AIF), named for its involvement in cell death pathways, is a mitochondrial protein that regulates metabolic homeostasis. In addition to supporting the survival of healthy cells, AIF also plays a contributory role to the development of cancer through its enzymatic activity, and we have previously shown that AIF preferentially supports advanced-stage prostate cancer cells.
15p
vinaypyidaw2711
26-08-2020
7
2
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Cancer cells exhibit an altered metabolism, which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role by transporting pyruvate into mitochondrial through the mitochondrial inner membrane.
12p
vimale2711
25-08-2020
7
2
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Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparaginase; however, the mechanism underlying their inter-individual differences is still not fully understood.
13p
vikuala271
13-06-2020
7
0
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Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a natural amino acid synthesized in the mitochondria, and various types of cytochromes containing heme contribute to aerobic energy metabolism.
11p
vienzym2711
30-03-2020
14
1
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The aim of the study was to evaluate the effect of titanium bone fixations on mitochondrial activity, reactive oxygen species (ROS) production, glutathione metabolism, and selected markers of oxidative/nitrosative stress in the periosteum-like tissue of patients treated with mandible fractures.
13p
vicaracas2711
27-11-2019
23
1
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The diagnosis of mitochondrial diseases is a real challenge because of the vast clinical and genetic heterogeneity. Classically, the clinical examination and genetic analysis must be completed by several biochemical assays to confirm the diagnosis of mitochondrial disease.
8p
vinasaki2711
12-11-2019
13
1
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Oxidative phosphorylation is a source of energy production by which many cells satisfy their energy requirements. Endogenous reactive oxygen species (ROS) are by-products of oxidative phosphorylation. ROS are formed due to the inefficiency of oxidative phosphorylation, and lead to oxidative stress that affects mitochondrial metabolism.
11p
vinasaki2711
12-11-2019
18
0
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(BQ) Contniued part 1, part 2 of the document Biochemistry essential has contents: Oxidative phosphorylation and mitochondrial diseases, glycogen metabolism and glycogen storage diseases, gluconeogenesis and fasting hypoglycemia, insulin and counterregulatory hormones,... and other contents. Invite you to refer.
239p
thuongdanguyetan06
06-06-2019
20
0
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Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism. Accumulation of ROS without an effective antioxidant response can lead to oxidative stress, resulting in macromolecular damage that is implicated in the etiology of various diseases including cancer.
6p
vikimsa
22-02-2019
17
1
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Department of Medical Biochemistry and Biology, University of Bari, Italy; 2Department of Zoology, Laboratory of Histology and Comparative Anatomy, University of Bari, Italy; 3Center for the Study of Mitochondria and Energy Metabolism (CNR) Bari, Italy Mitochondrial bioenergetic impairment has been found in the organelles isolated from rat liver during the prereplicative phase of liver regeneration.
9p
system191
01-06-2013
32
3
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Uncoupling protein-3 (UCP3) is a mitochondrial innermembrane protein abundantly expressed in rodent and human skeletal muscle which may be involved in energy dissipation. Many studies have been performed on the metabolic regulation of UCP3 mRNA level, but little is known about UCP3 expression at the protein level. Two populations of mitochondria have been described in skeletal muscle, subsarcolemmal (SS) and intermyofibrillar (IMF), which differ in their intracellular localization and possibly also their metabolic role....
7p
system191
01-06-2013
33
3
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The citric acid or tricarboxylic acid cycle is a central element of higher-plant carbon metabolism which provides, among other things, electrons for oxidative phosphorylation in the inner mitochondrial membrane, intermediates for aminoacid biosynthesis, and oxaloacetate for gluconeogenesis from succinate derived from fatty acids via the glyoxylate cycle in glyoxysomes. The tricarboxylic acid cycle is a typical mitochondrial pathway and is widespread among a-proteobacteria, the group of eubacteria as de®ned under rRNA systematics from which mitochondria arose. ...
16p
research12
01-06-2013
40
3
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To assess the expression and physiological role of the mitochondrial NAD + -independent lactate dehydrogenase (iLDH) inEuglena gracilis, cells were grown with different carbon sources, and theD-andL-iLDHactivities and several key metabolic intermediates were examined. iLDH activity was significant throughout the growth period, increasing by three- to fourfold from latency to the stationary phase. Intracellular levels ofD-andL-lactate were high (5–40 mM) fromthe start of the culture and increased (20–80 mM)when the stationaryphasewas entered....
10p
fptmusic
12-04-2013
32
1
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The mechanisms underlying increased cardioprotection in younger female mice are unclear. We hypothesized that serine-threonine protein kinase (protein kinase B; Akt) triggers a metabolic gene switch (decreased fatty acids, increased glucose) in female hearts to enhance mitochondrial bio-energetic capacity, conferring protection against oxidative stress.
7p
media19
04-03-2013
20
1
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Impaired mitochondrial function contributes to copper- and cadmium-induced cellular dysfunction. In this study, we used modular kinetic analy-sis and metabolic control analysis to assess how Cd 2+ and Cu 2+ ions affect the kinetics and control of oxidative phosphorylation in isolated rat liver mitochondria.
13p
vinaphone15
25-02-2013
51
1
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