Molecular investigation

Obstructive sleep apnea (OSA) is associated with increased risk of lung cancer mortality. Nevertheless, little is known about the underlying molecular mechanisms. This research aimed to investigate differentially expressed genes (DEGs) and explore their function in Lewis lung carcinoma (LLC)-bearing mice exposed to chronic intermittent hypoxia (CIH) by transcriptome sequencing.

10p vishanshan 27-06-2024 1 1   Download

GEFT is a key regulator of tumorigenesis in rhabdomyosarcoma (RMS), and overexpression of GEFT is significantly correlated with distant metastasis, lymph node metastasis, and a poor prognosis, yet the underlying molecular mechanism is still poorly understood. This study aimed to investigate and validate the molecular mechanism of GEFT-activated lncRNAs in regulating mTOR expression to promote the progression of RMS.

16p vishanshan 27-06-2024 2 1   Download

Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the clinical significance and molecular alterations underpinning PIMO-labeled tumor hypoxia is needed for future clinical application.

12p vikoch 27-06-2024 1 1   Download

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide. Inhibitor of kappa B kinase interacting protein (IKBIP) has been reported to promote glioma progression, but its role in other cancers remains unclear. This study aimed to investigate the role of IKBIP and its underlying molecular mechanisms in ESCC.

16p vikoch 27-06-2024 1 1   Download

NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types.

22p vikoch 27-06-2024 3 1   Download

Hepatocellular carcinoma (HCC) is the most common type of malignant liver tumor with poor prognosis. In this study, we investigated the expression of transforming growth factor beta regulator 4 (TBRG4) in HCC and its effects on the proliferation, invasion, and metastasis of HCC cells, and analyzed the possible molecular mechanisms.

17p vikoch 27-06-2024 1 1   Download

To elucidate these issues, a detailed study of the microstructure of amorphous V2O5 under pressure was needed. The spatial distributions of atoms, the link distributions and the geometrical distributions of the free volumes need to be fully investigated. The distribution of free volume in the amorphous V2O5 network also needs to be visualized. These are the main contents in this paper.

11p viambani 18-06-2024 2 1   Download

Crystalline structure of CaO-P2O5-SiO2 system at 3,000 K were investigated by molecular dynamic simulation. The models with different concentrations of P2O5 (5-40 mol%) were constructed by using Born-Mayer-Huggins potentials. The size of models was from 5,270-5,520 atoms. The local environment of elements and glassy-network structure were investigated in detail.

13p viambani 18-06-2024 5 1   Download

Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke.

456p vimeyers 29-05-2024 4 2   Download

Ebook "The plant cell wall: Methods and protocols" describes some of the methods which are currently applied to investigate the many aspects of the plant cell wall including its structure, biochemical composition, and metabolism, to name but a few. Each chapter is written by leading experts in cell wall research and is written with the aim that the protocol(s) can be carried out by someone without previous experience in that particular method or specifically in cell wall research.

319p dongmelo 27-05-2024 6 3   Download

In conclusion, sequence analysis may be useful for the rapid detection of STR resistance in MDR M. tuberculosis strains, which in turn could contribute to better control strategies of TB in Vietnam. Other molecular mechanisms associated with STR resistance in STR-resistant strains without mutations in the rpsL and rrs genes need to be further investigated.

11p dianmotminh02 03-05-2024 4 1   Download

The geometries and relative stabilities of 15 tautomeric forms and the corresponding isomers of the studied molecules have been identified and their relative stabilities are investigated. The potential energy profiles and intrinsic reaction coordinates (IRC) calculations along the proton transfer coordinates both in the ground and in the excited state are monitored as well. The impact of the donating (OMe) and withdrawing (NO2) groups on the single and double proton transfers are investigated both in the gas phase and solution.

9p dianmotminh02 03-05-2024 4 1   Download

This study focuses on examining the effect of the π bridge on the properties of the molecule. The structural parameters of the molecular geometry were optimized, the HOMO and LUMO energies were calculated and analyzed in detail. In addition, the absorption wavelength, excitation energy, vibration intensity and electron transfer were calculated through the time-dependent density functional theory (TD-DFT) method.

6p dianmotminh02 03-05-2024 4 2   Download

Ebook "Sensing in nature" is to provide a picture, as complete as possible, of the current state of knowledge of sensory systems in nature. The presentation in this book lies at the intersection of evolutionary biology, cell and molecular biology, physiology and genetics. Sensing in Nature is written by a distinguished panel of specialists and is intended to be read by biologists, students, scientific investigators and the medical community.

334p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Ten years of progress in GW/P body research" richly explores these original scienti fi c discoveries and many of the subsequent detailed studies of the components and functions of RNA processing that take place in GW/P bodies. The author list is truly impressive and reading the history will pique the interests of students and senior investigators, and hopefully, provide insights into future directions of the fi eld of RNA biology.

280p tracanhphuonghoa1007 22-04-2024 1 1   Download

Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

203p tracanhphuonghoa1007 22-04-2024 3 2   Download

Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.

327p tracanhphuonghoa1007 22-04-2024 3 3   Download

Ebook "Molecular spintronics: From organic semiconductors to self-assembled monolayers" will focus on the study of organic semiconductors spintronic devices, here Alq3-based spin valves. We will investigate magnetoresistance (MR) effects at room temperature using conventional ferromagnetic (FM) materials. These investigations were done wishing to improve the understanding on the two interfaces and disentangle their contributions on the spin polarization properties of the devices.

191p tracanhphuonghoa1007 22-04-2024 3 2   Download

In Vietnam, SMEDI syndrome in sows caused by PPV is nationwide and has been of concern since the early 1990s. Previous studies have investigated the prevalence of PPVs using serological testing and PCR methods. The objective of this study is to analyze the genotypic prevalence of PPVs and molecular characterization of VP gene of PPV2 from slaughtered pigs in Central Vietnam.

10p viritesh 02-04-2024 1 1   Download

Recent studies have used genome-wide data to investigate evolutionary mechanisms related to behavioral phenotypes, identifying widespread signals of positive selection. Here, we conducted a genome-wide investigation to study whether the molecular mechanisms involved in these traits were affected by local adaptation.

12p vibransone 28-03-2024 2 2   Download