Of replication agents

The efficacy of antiretroviral agents approved for the treat-ment of HIV-1 infection is limited by the virus’s ability to develop resistance. As such there is an urgent need for new ways of thinking about anti-HIV drug development, and accordingly novel viral and cellular targets critical toHIV-1 replication need to be explored and exploited. The retroviral RNA genome encodes for three enzymes essential for viral replication: HIV-1 protease (PR), HIV-1 reverse transcrip-tase (RT) and HIV-1 integrase (IN). ...

9p tumor12 22-04-2013 33 2   Download

Chronic hepatitis C virus (HCV) infection is a clinically important liver disease with limited therapeutic options in a significant proportion of patients. Therefore, novel efficient therapeutic agents are needed. Because the 5¢- and 3¢-untranslated regions (UTRs) of HCV are highly conserved and functionally important for HCV replication, they are attractive targets for RNA-cleaving ribozymes or small interfering RNAs (siRNAs).

13p dell39 27-03-2013 52 5   Download

The NS2B–NS3 protease complex is essential for the replication of dengue virus, which is the etiologic agent of dengue and hemorrhagic fevers, dis-eases that are a burden for the tropical and subtropical areas of the world. The active form of the NS3 protease linked to the 40 residues of the NS2B cofactor shows highly flexible and disordered region(s)...

13p inspiron33 25-03-2013 40 4   Download

Direct DNA-Interactive Agents DNA replication occurs during the synthesis or S-phase of the cell cycle, with chromosome segregation of the replicated DNA occurring in the M, or mitosis, phase. The G1 and G2 "gap phases" precede S and M, respectively. Historically, chemotherapeutic agents have been divided into "phase-nonspecific" agents, which can act in any phase of the cell cycle, and "phase-specific" agents, which require the cell to be at a particular cell cycle phase to cause greatest effect.

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Another local approach uses adenoviral-mediated expression of the tumor suppressor p53, which is mutated in a wide variety of cancers. This strategy has shown complete and partial responses in squamous cell carcinoma of the head and neck, esophageal cancer, and non-small cell lung cancer after direct intratumoral injection of the vector. Response rates (~15%) are comparable to those of other single agents.

5p konheokonmummim 03-12-2010 68 6   Download

bạn đã cấu hình Agent Ảnh chụp để bắt đầu ngay lập tức như được đề nghị, bạn có thể xác minh sự tiến bộ của các Đại lý Ảnh chụp bằng cách sử dụng Replication Monitor. Phần này của bài viết mô tả cách cấu hình Replication Monitor và làm thế nào để xem trạng thái của chất độc Ảnh chụp. 2.In SQL Server Management Studio, nhấp chuột phải vào thư mục các ấn phẩm địa phương và sau đó nhấp vào Launch Replication Monitor....

4p hangkute_2 04-08-2010 118 27   Download