Patient activation

Shingles is a common skin infection, caused by the latent Varicella zoster virus in the paraspinal cranial nerve ganglia, when there are favorable factors such as immunosuppression makes the virus active again. The disease greatly affects the patient's quality of life. Objectives: Survey to determine clinical manifestations, correlative factors and evaluate the results of topical treatment of herpes zoster with He-Ne laser combination at Can Tho DermatoVenereology Hospital in 2021.

8p viakimichi 17-01-2025 2 2   Download

Burns, especially heat-related ones, are one of the most common injuries in work and daily life. If patients are not treated properly, burns can leave a lot of sequelae which would negatively affect not only daily activities, working ability but also aesthetics and psychology of the patients. Most topical treatments have been reported that they have some adverse effects and unintentionally prolong the length of hospital stay.

7p vinara 11-01-2025 2 1   Download

Paracetamol is one of the most commonly used active ingredients, even without a doctor's prescription for most people. It has effects on relieving pain and treating fever, especially with an analgesic effect for the elderly who have to suffer from degenerative joint disease. However, the half-life of paracetamol is relatively short, from 1 to 3 hours, so patients need to use it many times a day.

9p vinara 11-01-2025 2 1   Download

Ostomy has become a common therapy for treating gastrointestinal diseases such as colorectal cancer. Patients with ostomy experience many problems including appearance change, uncontrolled discharge and odour, sexual dysfunction, decreased social functioning, and difficulties taking care of themselves. Because of these problems, many patients with ostomies feel anxious, unconfident and afraid to participate in social activities.

8p vinara 11-01-2025 1 1   Download

The master's thesis of Science: Cross-sectional survey: levels of engagement among surgical patients aimed to 1) understand how engagement is measured in surgical patients; 2) identify levels of engagement among surgical patients; and 3) determine whether patients’ levels of engagement are associated with decision making and information processing capabilities.

153p runthenight04 02-02-2023 7 3   Download

This study with the following objectives: Study some characteristics of immune disorders, analysis of association with target organ damage and activity level (SLEDAI score) in patients with severe systemic lupus erythematosus. Evaluation of treatment outcome of pulsed methylprednisolone therapy combined with baseline treatment after 12 weeks in patients with severe systemic lupus erythematosus.

34p petsematary 02-06-2021 29 4   Download

The K103N substitution is a frequently observed HIV-1 RT mutation in patients who do not respond to combinationtherapy. The drugs Efavirenz, MSC194 and PNU142721 belong to the recent generation of NNRTIs characterized by an improved resistance profile to the most common single point mutations within HIV-1 RT, including the K103N mutation. In the present study we present structural observations from Efavirenz in complex with wild-type protein and the K103N mutant and PNU142721 and MSC194 in complex with the K103N mutant.

8p system191 01-06-2013 43 4   Download

Staphylokinase (SAK) is a 15.5-kDa protein fromStaphy-lococcus aureusthat activates plasminogenby forminga1 : 1 complex with plasmin. Recombinant SAK has been shown in clinical trials to induce ®brin-speci®c clot lysis in patients withacutemyocardial infarction.However, SAKelicits high titers of neutralizing antibodies. Biochemical and protein engineering studies have demonstrated the feasibility of generatingSAKvariantswith reducedantigenicity yet intact thrombolytic potency.

7p research12 23-04-2013 45 3   Download

Theb-amyloid peptide (Ab) is a major component of toxic amyloid plaques found in the brains of patients with Alzheimer’s disease.Abis liberated by sequential cleavage of amyloid precursor protein (APP) byb-andc-secre-tases.The level of Abdepends directly on the hydrolytic activity ofb-secretase.Therefore, b-secretase is an excel-lent target for drug design.An approach based on RNA-cleaving ribozymes was developed to control expression ofb-secretase.

9p tumor12 20-04-2013 38 4   Download

Although efficient vaccines are available, chronic hepatitis B (HBV) infection poses a major health problem worldwide, and prolonged treatment of chronicallyinfected HBV patients with nucleoside analogs often results in drug-resistantHBVvariants.Therefore, it is critical toevaluate the contribution of the HBV polymerase to mutations. FLAG-taggedwild-type (FPolE) andmutant (FPolE/D551A)HBV polymerases have been expressed in insect cells and purified. The purified FPolE showed DNA polymerase activity, but FPolE/D551A did not, implying that the activity was derived from FPolE....

8p fptmusic 16-04-2013 41 3   Download

The C-peptide of proinsulin is important for the biosynthesis of insulin, but has been considered for a long time to be biologically inert. Recent studies in diabetic patients have stimulated a new debate about its possible regulatory role, suggesting that it is a hormonally active peptide. We des-cribe structural studies of the C-peptide using 2D NMR spectroscopy.

10p fptmusic 11-04-2013 33 2   Download

Hyaluronidase (E.C. 3.2.1.35), one of the three major allergens of yellow jacket venom, is a glycoprotein of 45 kDa that is largely responsible for the cross-reactivity of wasp and bee venoms with sera of allergic patients. The asparagine-linked carbohydrate often appears to constitute the com-mon IgE-binding determinant.

9p fptmusic 11-04-2013 46 4   Download

In the majority of hypophosphatasia patients, reductions in the serum lev-els of alkaline phosphatase activity are caused by various missense muta-tions in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. A unique frame-shift mutation due to a deletion of T at cDNA number 1559 [TNSALP (1559delT)] has been reported only in Japanese patients with high allele frequency.

14p awards 06-04-2013 46 4   Download

Human airway trypsin-like protease (HAT), a serine protease found in the sputum of patients with chronic airway diseases, is an agonist of protease-activated receptor-2 (PAR-2). Previous results have shown that HAT enhances the release of amphiregulin (AR); further, it causes MUC5AC gene expression through the AR-epidermal growth factor receptor pathway in the airway epithelial cell line NCI-H292.

13p dell39 27-03-2013 35 2   Download

Gaucher disease is an autosomal recessive lysosomal storage disorder caused by the deficient activity of glucocerebrosidase. Accumulation of glucosylceramide, primarily in the lysosomes of cells of the reticuloendo-thelial system, leads to hepatosplenomegaly, anemia and skeletal lesions in type I disease, and neurologic manifestations in types II and III disease.

11p inspiron33 25-03-2013 53 4   Download

Lys101Glu is a drug resistance mutation in reverse transcriptase clinically observed in HIV-1 from infected patients treated with the non-nucleoside inhibitor (NNRTI) drugs nevirapine and efavirenz. In contrast to many NNRTI resistance mutations, Lys101(p66 subunit) is positioned at the sur-face of the NNRTI pocket where it interacts across the reverse transcrip-tase (RT) subunit interface with Glu138(p51 subunit).

11p inspiron33 25-03-2013 28 5   Download

Primary cultured fibroblasts of four patients with idiopathic short stature and severe growth delay, which displayed normal growth hormone receptor expression presented a reduced ability for activation of signal transducer and activator of transcription-3 (STAT3). Impaired STAT3 activation was accompanied by cell-cycle arrest at the Go⁄G1 phase.

13p inspiron33 25-03-2013 47 3   Download

Beta-amyloid (1–40) (Abeta), the main component of senile plaques seen in the brains of Alzheimer’s disease patients, was found to be toxic both as fibrils and smaller soluble globular aggregates. The hydrolytic properties of Abeta, a new biochemical activity described previously [Brzyska M, Bacia A & Elbaum D (2001)Eur J Biochem268, 3443–3454], may contribute to its overall toxicity.

14p inspiron33 23-03-2013 39 4   Download

The activity of NTPDase (EC 3.6.1.5, apyrase, CD39) was verified in plate-lets from patients with increasing cholesterol levels. A possible association between cholesterol levels and inflammatory markers, such as oxidized low-density lipoprotein, highly sensitive C-reactive protein and oxidized low-density lipoprotein autoantibodies, was also investigated.

8p galaxyss3 19-03-2013 50 4   Download

Friedreich’s ataxia results from a deficiency in the mitochondrial protein frataxin, which carries single point mutations in some patients. In the pres-ent study, we analysed the consequences of different disease-related muta-tions in vitro on the stability and dynamics of human frataxin.

11p galaxyss3 07-03-2013 41 4   Download