Báo cáo khoa học: Crystal structure of a staphylokinase variant A model for reduced antigenicity
43
lượt xem 3
download
lượt xem 3
download
Download
Vui lòng tải xuống để xem tài liệu đầy đủ
Staphylokinase (SAK) is a 15.5-kDa protein fromStaphy-lococcus aureusthat activates plasminogenby forminga1 : 1 complex with plasmin. Recombinant SAK has been shown in clinical trials to induce ®brin-speci®c clot lysis in patients withacutemyocardial infarction.However, SAKelicits high titers of neutralizing antibodies. Biochemical and protein engineering studies have demonstrated the feasibility of generatingSAKvariantswith reducedantigenicity yet intact thrombolytic potency.
Chủ đề:
Bình luận(0) Đăng nhập để gửi bình luận!
CÓ THỂ BẠN MUỐN DOWNLOAD