![](images/graphics/blank.gif)
Possible modulator
-
Efflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this study we assessed the heritability of the pharmacokinetics of talinolol as a putative probe drug for MDR1 and possibly other membrane transporters.
12p
vioraclene
31-03-2024
10
2
Download
-
Can computers meaningfully process human language? If this is difficult, why? If this is possible, how? This book introduces the reader to the fascinating science of computational linguistics and automatic natural language processing, which combines linguistics and artificial intelligence.
198p
haojiubujain08
01-11-2023
6
2
Download
-
Software design - Lecture 7. The main topics covered in this chapter include: tree-structures; possible solution - subsystem based; possible solution - layer based; another definition of information hiding; module's interface specification; database management system;...
15p
haoasakura
30-05-2022
14
3
Download
-
An increasing number of conditions appear to benefit from control and modulation of temperature, but available techniques to control temperature often have limitations, particularly in smaller patients with high surface to mass ratios. We aimed to evaluate a new method of temperature modulation with an esophageal heat transfer device in a pediatric swine model, hypothesizing that clinically significant modulation in temperature (both increases and decreases of more than 1°C) would be possible.
6p
viisaacnewton
26-04-2022
5
1
Download
-
Little is known regarding the role of gender as a possible modulator in determining the associations between lifestyle risk factors and depression in older adults. This study examined whether gender modulates the relationship between depression and lifestyle risk factors in Korean adults aged 65 years and older (n=3700).
10p
vinobelprisen
26-03-2022
6
4
Download
-
The aim of the study was to investigate the effects of chronic administration of parecoxib, a cyclooxygenase-2 inhibitor, on anxiety behavior and memory performance under normal physiological conditions and to explore the possible neural mechanism underlying parecoxib-mediated effects.
8p
vampires36
30-12-2021
6
0
Download
-
microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control posttranscriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell communication, and anti-cancer immunity.
12p
vidietmarhopp
28-12-2021
6
0
Download
-
Determination of genome-wide DNA methylation is significant for both basic research and drug development. As a key epigenetic modification, this biochemical process can modulate gene expression to influence the cell differentiation which can possibly lead to cancer.
10p
visilicon2711
20-08-2021
12
1
Download
-
"Lesson Instructor materials - Module 5: Number systems" present expose learners to new skills and concepts; expose learners to new skills and concepts; try to include as many questions as possible to keep students engaged during classroom presentation; give your students plenty of practice and additional exercises until they have mastered the hexadecimal numbering system...
28p
toidohang
11-06-2021
13
1
Download
-
"Lesson Instructor materials - Module 10: Basic router configuration" present to facilitate learning, the following features within the GUI may be included in this module; review the activities and assessments for this module; try to include as many questions as possible to keep students engaged during classroom presentation.
39p
toidohang
11-06-2021
19
2
Download
-
Idiopathic genu valgum is a frequently diagnosed growth disorder in adolescence. Whenever the possibilities of conservative therapy have been exhausted, leg straightening by means of hemiepiphysiodesis has become the standard form of treatment.
8p
vitennessee2711
02-02-2021
14
2
Download
-
Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery. However, the applicability of metabolite-likeness in drug discovery has been largely unexplored.
10p
viflorida2711
30-10-2020
12
2
Download
-
Characterizing the modular structure of cellular network is an important way to identify novel genes for targeted therapeutics. This is made possible by the rising of high-throughput technology. Unfortunately, computational methods to identify functional modules were limited by the data quality issues of high-throughput techniques.
15p
vijisoo2711
27-10-2020
10
0
Download
-
Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no significant results have been reached so far to prevent hormone non-responsive tumors.
10p
vijisoo2711
30-09-2020
6
1
Download
-
Cancer research has devoted most of its energy over the past decades on unraveling the control mechanisms within tumor cells that govern its behavior. From this we know that the onset of cancer is the result of cumulative genetic mutations and epigenetic alterations in tumor cells leading to an unregulated cell cycle, unlimited replicative potential and the possibility for tissue invasion and metastasis.
12p
vijisoo2711
30-09-2020
5
1
Download
-
The microenvironment modulates tissue specificity in the normal breast and in breast cancer. The stromal loss of CD34 expression and acquisition of SMA myofibroblastic features may constitute a prerequisite for tumor invasiveness in breast carcinoma.
9p
virose2711
22-09-2020
16
2
Download
-
Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibility that CDK5 modulation could have therapeutic benefit.
16p
vimoscow2711
29-08-2020
7
1
Download
-
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisation, possibly reducing hypoxia. However, the exact mechanism underlying these effects remains unclear.
10p
vinaypyidaw2711
26-08-2020
13
1
Download
-
We reported previously that root elongation in Arabidopsis is promoted by exogenous proline, raising the possibility that this amino acid may modulate root growth.
14p
vihashirama2711
21-05-2020
17
2
Download
-
Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.
13p
caothientrangnguyen
09-05-2020
20
0
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)