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Protein stability
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The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.
18p
dianmotminh02
03-05-2024
2
1
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Ebook "Membrane proteins production for structural analysis" updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.
441p
ladongphongthanh1008
22-04-2024
1
1
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Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellectual and physical disabilities for the children undergoing treatment. Thus, there is an urgent need for improved, targeted therapies that minimize these harmful side effects.
15p
vibransone
28-03-2024
4
2
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PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients.
17p
vibransone
28-03-2024
1
1
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Ebook "Tetramer stability and functional regulation of tumor suppressor protein p53" presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis.
82p
coduathanh1122
27-03-2024
1
1
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Ebook Biophysics: Part 1 includes contents: Laser correlation spectroscopy - nutritional, ecological and toxic aspects; microtools for microsurgery of a single cell in field of cellular engineering, an interfacial thermodynamics model for protein stability,... and other contents.
144p
longtimenosee03
30-01-2024
5
2
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Part 1 book "Milk proteins - From expression to food" includes content: The world supply of food and the role of dairy protein; milk - an overview; the comparative genomics of monotremes, marsupials, and pinnipeds - models to examine the functions of milk proteins; significance, origin, and function of bovine milk proteins - the biological implications of manipulation or modification; post translational modifications of caseins; casein micelle structure and stability; structure and stability of whey proteins; ... and other contents.
285p
muasambanhan03
02-01-2024
7
2
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Tensoactive species obtained by papain hydrolysis of soy protein were characterized structurally and physicochemically, and their foam-forming and -stabilizing capacity studied. Protein structural changes upon reaction ending were correlated with functional and interfacial properties and with the behaviour thereof with varying hydrolysis degree.
9p
viisac
23-09-2023
5
1
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Telomeres are DNA-protein complexes that cap chromosomal ends to promote chromosomal stability. Telomere length has been associated with diet and nutrition and inversely associated with mortality, life stress, and diseases. The objective of the current study was to explore the effect of long-term intake of multiple dietary supplements on telomere length in adults compared with age-matched controls.
6p
viisac
23-09-2023
3
1
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Albumin is a water-soluble protein that has attracted attention due to its characteristics, including biocompatibility, biodegradability, non-immunogenicity, long half-life, minimal toxicity, good stability, and good reactivity. These good characteristics make albumin can be applied in various fields. Albumin can be used in medical and pharmacy as drug delivery and infusion therapy.
16p
viberbers
09-08-2023
5
2
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The effects of inert spherical crowders on the melting temperature and the folding stability of small globular proteins are investigated by using molecular dynamics simulations with a Go-like model for the proteins.
10p
vispiderman
15-06-2023
3
2
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In this study, we investigated the total protein index, total anthocyanins and delphinidin 3.5'- diglucoside contents from black bean and fermented bean by Aspergillus oryzae using different steaming process. Based on the research results, it is possible to orient the production of fermented bean products with high nutritional contents and natural colors, without using chemicals.
7p
vidoctorstrange
06-05-2023
2
1
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Post-transcriptional regulation is the control of gene expression at the RNA level. After produced, the stability and distribution of the different transcripts are regulated by means of RNA-binding proteins (RBPs).
8p
vicaptainmarvel
21-04-2023
11
2
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In this Masters thesis computational modelling techniques were employed to investigate iron-free apo-Lactoferrin (apo-Lf) structural conformation changes in the presence of variant temperature and pH. These conditions represent the environment most milk protein goes through in food processing and the production of food products.
162p
runthenight04
02-02-2023
5
2
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Majority of 37 human aminoacyl tRNA synthetases have been incriminated in diverse, mostly recessive, genetic diseases. In accordance with this, we uncovered a novel homozygous valyl-tRNA synthetase 1 (VARS1) gene variant, leading to p.T1068M mutation. As in the previously reported VARS1 mutations, the affected individual harboring p.T1068M was experiencing a neurodevelopmental disorder with intractable seizures, psychomotor retardation, and microcephaly.
12p
lyhuyenthu
31-01-2023
5
2
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In the current study, the effect of USP7 on pluripotency maintenance of mouse ESCs (mESCs) has been investigated with the help of cell viability assay, morphological analysis, alkaline phosphatase (ALP) staining, qPCR analysis, and Western Blotting. 600 nM P5091 application, which showed no significant toxicity in mESCs, increased the total ubiquitinated protein amount as a proof of the accomplishment of proper USP7 inhibition.
14p
lyhuyenthu
31-01-2023
8
3
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Incorporation of therapeutic proteins in a matrix of sugar glass is known to enhance protein stability, yet protection is often lost when exposed to high relative humidity (RH). We hypothesized that especially in these conditions the use of binary glasses of a polysaccharide and disaccharide might yield advantages for protein stability.
7p
vihermione
06-01-2023
5
2
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In the present work, the structuring and stabilising potential of flaxseed gum (FG) in whey protein isolate (WPI) cryo-hydrogels was investigated. The FG presence (0.1–1% wt.) in the heat-treated WPI dispersions (10% wt.) induced strong segregative phase separation phenomena, which were associated with a depletion flocculation mechanism.
12p
viginny
30-12-2022
8
2
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Staphylococcal protein A affinity chromatography is a well-established platform for purification of clinical-grade antibodies. The wild type ligand has been mutated to improve caustic stability, elution behavior, and/or to increase binding capacity.
10p
viginny
23-12-2022
5
3
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Platform manufacturing processes are widely adopted to simplify and standardize the development and manufacturing of monoclonal antibodies (mAbs). However, there are mAbs that do not conform to a platform design due to instability or other protein properties leading to a negative impact on product quality or process performance (non-platform mAb).
9p
viginny
23-12-2022
7
3
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