Reports in physics

This study primarily concentrates on the metaphors used in economic reports. Its aim is to have an insight into how metaphors are correlated to human physical experience and constructed in economic reports. In addition, the analysis of this correlation will set foundation for later categorization of the source domains which are exploited in the metaphors in these economic reports.

87p closefriend09 16-11-2021 23 4   Download

The phenomenon of the transformation of proteins into amyloid-fibrils is of interest, firstly, because it is closely connected to the so-called conformational diseases, many of which are hitherto incurable, and secondly, because it remains to be explained in physical terms (energetically and structurally). The process leads to fibrous aggregates in the form of extracellular amyloid plaques, neuro-fibrillary tangles and other intracytoplasmic or intranuclear inclusions.

10p research12 01-06-2013 32 4   Download

The search for endogenousdigitalishas led to the isolationof ouabain as well as several additional cardiotonic steroids of the cardenolide and bufadienolide type from blood, adre-nals, and hypothalamus.The concentration of endogenous ouabain is elevated in blood upon increased Na + uptake, hypoxia, and physical exercise.Changes in blood levels of ouabain upon physical exercise occur rapidly.

9p research12 29-04-2013 38 3   Download

Mammalian alcohol dehydrogenases (ADH) 3 form a com-plex enzyme system based on amino-acid sequence, func-tional properties, and gene expression pattern. At least four mouseAdhgenes are known to encode di€erent enzyme classes that share less than 60% amino-acid sequence iden-tity. Two ADH-containing and overlapping C57BL/6 bacterial arti®cial chromosome clones, RP23-393J8 and -463H24, were identi®ed in a library screen, physically mapped, and sequenced.

9p research12 29-04-2013 22 2   Download

ThenblAfamily of genes encodes for small proteins neces-sary for the ordered degradation of phycobilisomes under certain stress conditions, a process known as chlorosis. Genes homologous tonblAseem to occur in all phycobili-some-containingorganisms.However, todate, nomolecular mechanism is known for the action of NblA, nor have the gene products been characterized to understand the physical properties of the molecule and thus help elucidate the mechanism on a structural basis.

8p research12 23-04-2013 45 4   Download

The interaction of bacterial endotoxins [lipopolysaccharide (LPS) and the
endotoxic principle lipid A], with high-den-sity lipoprotein (HDL) from serum was investigated with a variety of physical techniques and biological assays. HDL exhibited an increase in the gel to liquid crystalline phase transition temperature Tc and a rigidification of the acyl chains of the endotoxins as measured by Fourier-transform infrared spectroscopy and differential scanningcalorimetry.

10p tumor12 22-04-2013 38 3   Download

The classical metabolic control theory [Kacser, H. & Burns, J.A. (1973)Symp.Soc.Exp.Biol. 27, 65–104; Heinrich, R. & Rapoport, T. (1974)Eur. J. Biochem.42, 89–95.] does not take into account experimental evidence for correlations between enzyme concentrations in the cell. We investigated the implications of two causes of linear correlations: competition between enzymes, which is a mere physical adaptation of the cell to the limitation of resources and space, and regulatory correlations, which result from the existence of regulatory networks....

17p awards 05-04-2013 49 3   Download

Endotoxin-neutralizingprotein (ENP) of the horseshoe crab isoneof themost potent neutralizersof endotoxins [bacterial lipopolysaccharide (LPS)]. Here, we report on the inter-action of LPS with recombinant ENP using a variety of physical and biological techniques. In biological assays (Limulusamebocyte lysate and tumour necrosis factor-a induction in human mononuclear cells), ENP causes a strong reduction of the immunostimulatory ability of LPS in a dose-dependent manner.

10p dell39 03-04-2013 38 3   Download

L-Arabinitol 4-dehydrogenase (Lad1) of the cellulolytic and hemicellulolytic fungusHypocrea jecorina(anamorph: Trichoderma reesei) has been implicated in the catabolism ofL-arabinose, and genetic evidence also shows that it is involved in the catabolism of D-xylose in xylitol dehydrogenase (xdh1) mutants and of D-galactose in galactokinase (gal1) mutants of H. jecorina.In order to identify the substrate specificity of Lad1, we have recombinantly produced the enzyme inEscherichia coliand purified it to physical homogeneity....

9p dell39 03-04-2013 31 3   Download

The transient receptor potential channel vanilloid receptor subunit 1 (TRPV1) is amolecular integrator of physical and chemical stimuli in the peripheral nociceptor terminals. TRPV1 is an ionotropic channel that plays a critical role in both thermal nociception and inflammatoryhyperalgesia. Structure–function relationships are providing fundamental insights of the modular architecture of this neuronal recep-tor.

7p dell39 03-04-2013 46 3   Download

The introduction of noncanonical amino acids and bio-physical probes into peptides and proteins, and total or segmental isotopic labelling has the potential to greatly aid thedeterminationofproteinstructure, functionandprotein– protein interactions.To obtain a peptide as large as possible by solid-phase peptide synthesis, native chemical ligation was introduced to enable synthesis of proteins of up to 120 amino acids in length.

15p dell39 03-04-2013 43 4   Download

Surfactant-like membranes containing the 21-residue peptide KLLLL-KLLLLKLLLLKLLLLK (KL4 ), have been clinically tested as a therapeu-tic agent for respiratory distress syndrome in premature infants. The aims of this study were to investigate the interactions between the KL4 peptide and lipid bilayers, and the role of both the lipid composition and KL4 structure on the surface adsorption activity of KL4 -containing membranes.

13p inspiron33 26-03-2013 40 4   Download

Human amylin is a small fibrillogenic protein that is the major constituent of pancreatic islet amyloid, which occurs in most subjects with type 2 dia-betes. There is evidence that it can elicitin vitro apoptosis in isletb-cells, but the physical properties that underpin its cytotoxicity have not been clearly elucidated.

11p inspiron33 25-03-2013 40 5   Download

The nano-scale spatial organization of metallic and other inorganic materi-als into 1D objects is a key task in nanotechnology. Nano-scale fibers and tubes are very useful templates for such organization because of their inherent 1D organization. Fibrillar biological molecules and biomolecular assemblies are excellent physical supports on which to organize the inor-ganic material.

6p inspiron33 23-03-2013 38 4   Download

DNA polymeraseeco-operates with polymerasesaanddin the replicative DNA synthesis of eukaryotic cells. We describe here a specific physical interaction between DNA polymerase eand RNA polymerase II, evidenced by reciprocal immunoprecipitation experiments. The interacting RNA polymerase II was the hyperphosphorylated IIO form implicated in tran-

15p inspiron33 23-03-2013 44 3   Download

While the importance of Ca2+ channel activity in axonal path finding is established, the underlying mechanisms are not clear. Here, we show that transient receptor potential vanilloid receptor 1 (TRPV1), a member of the TRP superfamily of nonspecific ion channels, is physically and functionally present at dynamic neuronal extensions, including growth cones.

13p galaxyss3 21-03-2013 47 5   Download

Enzymes from psychrophiles show higher catalytic efficiency in the 0–20C temperature range and often lower thermostability in comparison with meso⁄thermophilic homologs. Physical and chemical characterization of these enzymes is currently underway in order to understand the molecular basis of cold adaptation.

14p media19 04-03-2013 24 1   Download

Sister chromatid cohesion is important for the correct alignment and segre-gation of chromosomes during cell division. Although the cohesin complex has been shown to play a physical role in holding sister chromatids together, its loading onto chromatin is not sufficient for the establishment of sister chromatid cohesion.

14p vinaphone15 28-02-2013 30 2   Download

We investigated the soluble forms of the earliest activation antigen of human leukocyte CD69. This receptor is expressed at the cell surface as a type II homodimeric membrane protein. However, the elements necessary to prepare the soluble recombinant CD69 suitable for structural studies are a matter of controversy.

18p vinaphone15 28-02-2013 37 3   Download

Vnd is a dual transcriptional regulator that is essential forDrosophila dor-sal–ventral patterning. Yet, our understanding of the biochemical basis for its regulatory activity is limited. Consistent with Vnd’s ability to repress target expression in embryos, endogenously expressed Vnd physically asso-ciates with the co-repressor, Groucho, inDrosophilaKc167 cells.

12p vinaphone15 28-02-2013 37 4   Download