Selection of chemicals

Master's thesis of Science "Investigation into the modulation of circadian clock proteins by dietary compounds and small molecules" is structured as follows: Chapter 1 Introduction; Chapter 2 Identification of novel bioactive compounds from Olea europaea by evaluation of chemical compounds in the OliveNetTM library: in silico bioactivity and molecular modelling, and in vitro validation of hERG activity; Chapter 3 Modulation of circadian core clock proteins by dietary compounds; Chapter 4 Molecular mechanisms of action of selected olive phenolics against epigenetic modifiers and the structur...

235p runthenight04 02-02-2023 3 2   Download

The study "Studies on film forming corrosion inhibitors on aluminium alloy, AA2024-T3" presents key aspects of the film forming behaviour of the selected inhibitors and the test methods used to evaluate the inhibitor induced films in a chloride solution. This study also aims to provide significant insights to the film tenacity, the influence of the molecular structure as well as the film stability in the absence of inhibitors to provide a deeper understanding of the film forming and film breakdown mechanisms.

154p runthenight04 02-02-2023 11 2   Download

Lentic systems are a diverse set of inland freshwater habitats (Lakes and ponds) exist across the globe and provide essential resources and habitats for both terrestrial and aquatic organisms. The current work was intended to evaluate the quality of the selected ponds (Pond 1, 2 and 3) in and around Vellore district, TamilNadu. The water samples were collected to determine the physical and chemical parameters during every month in the year 2019. Water parameters such as temperature, pH, dissolved oxygen, Alkalinity, electrical conductivity, Chloride, Sulphate, Nitrate, Ca, Cl was studied.

10p angicungduoc6 22-07-2020 26 2   Download

An experiment was conducted to generate a broad genetic variability through induced mutation using physical and chemical mutagens. Three doses each of gamma rays (20, 40 and 60kR), ethyl methane sulphonate (0.2, 0.4 and 0.6%), nitrosoguanidine (0.005, 0.010, and 0.015%), maleic hydrazide (0.01, 0.02 and 0.03%) and their combinations were administered to the seed of two greengram varieties, Sujata and OBGG-52.

13p angicungduoc6 22-07-2020 20 2   Download

The study was carried out during 2013-14 in Meerut district of Uttar Pradesh state to focus on the sugarcane growers regarding impact of knowledge on adoption level of IPM practices. The 80 contact farmers were selected as respondents. The study revealed that the maximum knowledge gap was found to be existing in previous crop residues, crop rotation, hand picking of the insect and their destruction, hot air and water treatment, light and pheromone trap, microbial control, use of natural enemies, resistant varieties, biopesticides/ bio-agents, application and dose of different pest etc.

7p chauchaungayxua6 26-06-2020 20 3   Download

This paper evaluates the inventory management policies of four major petro chemical industries in India. The companies were selected on the basis of turnover. The financial statements of the companies for 5 years from 2012-2016 were considered for the study.

7p guineverehuynh 22-06-2020 11 1   Download

Pest control practices in the vegetable crops have been heavily dominated by the routine use of broad-spectrum insecticides to control pests. Concerns have emerged about the adverse consequences of over use of pesticide. These consequences include short and longterm health hazards, contamination and environmental degradation. To minimize the pest losses farmers heavily depend on the chemical pesticides and accessing pest management information from the pesticide dealers due to weak state extension support system.

9p nguaconbaynhay5 16-05-2020 18 2   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 12 0   Download

The thesis aims to investigate and select suitable conditions for synthesis of Nanocompozit Silica / Polypyrol by In-situ method. Nature and study of corrosion inhibition ability of Silica / Polypyrol carbon steel. Select suitable conditions for synthesis of silica / Polypyrol anionic doped for In-situ method. Corrosion inhibitory ability for Nanocompozit Silica / Polypyrol-Anion Carbon steel for polybutyral coating. Corrosion protection for carbon steel of epoxy coating containing SiO2 / polypyrol-anion composite.

27p xacxuoc4321 09-07-2019 51 4   Download

The research goals of the dissertation: The research separates, identifies structural characteristics and tests biological activity of fucoidan from several brown algae growing up in Vietnamese Seas to serve for investigating Vietnamese natural sea compound resources and making clear the chemical nature of research objects.

26p xacxuoc4321 09-07-2019 29 6   Download

These SAR achievements with virus diseases in tobacco, papaya, chilli, potato and cucumber mean that promising results can be expected if SAR method is applied to RGSD and RRSD in rice. If successful, we can introduce this method to help farmers limit damage when they cannot avoid BPH at the beginning of crop. To reach this aim, the study was conducted in the net-house to find the best effective chemicals in SAR to RGSD if the rice plants were infected early, at 7 days after sowing.

7p thiendiadaodien_9 04-03-2019 23 3   Download

The results of the reaction of selective reduction of NOx by C3H6 on the catalyst Cu/ZSM-5 with the presence of oxygen shown that there was a monotone relation between conversion degree of NOx and the amount of chemically adsorbed NOx [1]. Besides, the existence of amount of irreversiblely adsorbed C3H6 (C3H6ir) on the surface of catalyst Cu/ZSM-5 was detected [2]. The results of the role of C3H6irr towards reduction activity NOx in the studied reaction is presented in this article.

4p uocvong04 24-09-2015 25 3   Download

Four substrate analogs, 4-(2-naphthyloxy)-2-butyn-1-amine (1), 1,4-diamino-2-chloro-2-butene (2), 1,6-diamino-2,4hexadiyne (3), and 2-chloro-5-phthalimidopentylamine (4) have been tested as inhibitors against mammalian, plant, bacterial, and fungal copper-containing amine oxidases: bovine plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO), pea seedling amine oxidase (PSAO), Arthrobacter globiformis amine oxidase (AGAO), Escherichia coli amine oxidase (ECAO), and Pichia pastoris lysyl oxidase (PPLO).

14p research12 01-06-2013 43 6   Download

In this paper we address the problem of extracting features relevant for predicting protein±protein interaction sites from the three-dimensional structures of protein complexes. Our approach is based on information about evolutionary con-servation and surface disposition. We implement a neural network based system, which uses a cross validation proce-dure and allows the correct detection of 73% of the residues involved in protein interactions in a selected database comprising 226 heterodimers.

6p research12 29-04-2013 30 3   Download

It has previouslybeen shown that IFN-ais apotent inhibitor of IL-2 induced proliferation in primary T-lymphocytes, by selectively abrogating the downstream e€ects of IL-2 on the core cell cycle machinery regulating the G1/S transition. Theoretically this could be mediated through cross-talk between the signalling cascades activated by these cytokines, as several signalling components are known to be shared.

9p research12 29-04-2013 43 4   Download

The large intestine of breast-fed infants is colonized predominantly by bi®dobacteria, which have a protective e€ect against acute diarrhea. In this study we report for the ®rst time the identi®cation of human milk peptides that selectively stimulate the growth of bi®dobacteria. Several bi®dogenicpeptideswerepuri®edchromatographically from pepsin-treated human milk and identi®ed as proteolytically generated fragments from the secretory component of the soluble polyimmunoglobulin receptor and lactoferrin;...

7p research12 23-04-2013 44 2   Download

The vanilloid-like TRP-channel VRL-1 (TRPV2) is a non-selective cation channel expressed by primary sensory neurons and non-neuronal tissues [Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J and Julius, D. (1999) Nature398, 436–441]. It is one of the six members of the vanilloid-like TRP-channel family which is now termed the TRPV family [Montell, G., Birnbaumer, L., Flockerzi, V., Bindels, R.J., Brutford, E.A., Caterina, M.J., Clapham, D.E., Harteneck, C., Heller, S., Julius, D., Kojima, I., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A.M., Schultz, G., Shimizu, N. and Zhu, M.X.

8p tumor12 20-04-2013 28 3   Download

Glycogen synthase kinase 3 (GSK3) is inactivated by insulin and lithium and, like insulin, Li also activates glycogen synthase (GS)viainhibition of GSK3. Li also mimics insu-lin’s ability to stimulate glucose transport (GT), an obser-vation that has led to the suggestion that GSK3 may coordinate hormonal increases in GT and glycogen synthe-sis. Here we have used Li and SB-415286, a selective GSK3 inhibitor, to establish the importance of GSK3 in the hor-monal activation of GT in terms of its effect on GS in L6 myotubes and3T3-L1adipocytes. ...

10p tumor12 20-04-2013 33 4   Download

The selective manipulation of the expression and replica-tion of mitochondrial DNA (mtDNA) within mammalian cells has proven difficult. In progressing towards this goal we synthesized a novel mitochondria-targeted DNA-alkylating reagent. The active alkylating moiety [(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c] [1,4]benzodiazepin-5-one (DC-81)], irreversibly alkylates guanine bases in DNA (with a preference for AGA tri-plets), preventing its expression and replication.

10p fptmusic 16-04-2013 33 4   Download

Three mammalian ADAMTS enzymes, ADAMTS-1, -4 and -5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for car-tilage aggrecan catabolismobservedduring the development of arthritis. We have previously reported that certain cate-chins, polyphenolic compounds found in highest concen-trationingreentea(Camellia sinensis), are capable of inhibiting cartilage aggrecan breakdown in anin vitromodel of cartilage degradation.

10p fptmusic 16-04-2013 30 3   Download