Signaling and regulatory knowledge

A rapidly growing amount of knowledge about signaling and gene regulatory networks is available in databases such as KEGG, Reactome, or RegulonDB. There is an increasing need to relate this knowledge to highthroughput data in order to (in)validate network topologies or to decide which interactions are present or inactive in a given cell type under a particular environmental condition.

13p vioklahoma2711 19-11-2020 9 0   Download

Integrating genome-wide gene expression patient profiles with regulatory knowledge is a challenging task because of the inherent heterogeneity, noise and incompleteness of biological data. From the computational side, several solvers for logic programs are able to perform extremely well in decision problems for combinatorial search domains.

14p vicolorado2711 23-10-2020 23 1   Download

Insulin is the principal regulatory hormone involved in the tight regulation of fuel metabolism. In response to blood glucose levels, it is secreted by the b cells of the pancreas and exerts its effects by binding to cell surface receptors that are present on virtually all cell types and tissues. In humans, perturbations in insulin function and/or secretion lead to diabetes mellitus, a severe disorder primarily characterized by an inability to maintain blood glucose homeostasis. Furthermore, it is estimated that 90–95% of diabetic patients exhibit resistance to insulin action....

10p research12 01-06-2013 33 3   Download

Metabolically unstable proteins are involved in a multitude of regulatory networks, including those that control cell signaling, the cell cycle and in many responses to physiological stress. In the present study, we have deter-mined the stability and characterized the degradation process of some members of the Gq class of heterotrimeric G proteins. Pulse-chase experi-ments in HEK293 cells indicated a rapid turnover of endogenously expressed Gaq and overexpressed Gaq and Ga16 subunits.

13p fptmusic 12-04-2013 36 1   Download

Accumulating evidence indicates that G protein signaling plays an active role in the regulation of cell survival. Our previous study demonstrated the regulatory effects of Gi⁄ o proteins in nerve growth factor-induced activa-tion of pro-survival Akt kinase. In the present study we explored the role of various members of the Gs,Gq⁄ 11 and G12⁄ 13 subfamilies in the regula-tion of Akt in cultured mammalian cells.

11p inspiron33 26-03-2013 43 3   Download

This review discusses the talks presented at the third EMBL Biennial Sym-posium, From functional genomics to systems biology, held in Heidelberg, Germany, 14–17 October 2006. Current issues and trends in various sub-fields of functional genomics and systems biology are considered, including analysis of regulatory elements, signalling networks, transcription networks, protein–protein interaction networks, genetic interaction networks, medical applications of DNA microarrays, and metagenomics.

10p galaxyss3 21-03-2013 39 2   Download

Prokineticins are a novel family of secreted peptides with diverse regulatory roles, one of which is their capacity to modulate immunity in humans and in other species. Prokineticins are small peptides of 8 kDa that mediate their biological activities by signaling through two homologous G-protein-coupled receptors (prokineticin receptor 1 and prokineticin receptor 2).

8p galaxyss3 07-03-2013 38 2   Download

Sugars play important roles as both nutrients and regulatory molecules throughout plant life. Sugar metabolism and signalling function in an intri-cate network with numerous hormones and reactive oxygen species (ROS) production, signalling and scavenging systems.

16p mobifone23 21-01-2013 49 3   Download

Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transduction that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling molecules in this context is a central component of cancer research.

349p spy107 11-10-2012 51 5   Download

Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem death resides in the rostral ventrolateral medulla (RVLM) because it is the origin of a life-and-death signal that sequentially increases (pro-life) and decreases (pro-death) to reflect the advancing central cardiovascular regulatory dysfunction during the progression towards brain stem death in critically ill patients.

12p toshiba23 18-11-2011 51 1   Download

Abstract Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells and epidermal keratinocytes. Dysregulated cytokine production, orchestrated by activated T-cells homing to the skin, is believed to be the main cause of psoriasis, a common inflammatory skin disorder.

19p toshiba23 18-11-2011 51 2   Download