Small RNA

This study aims to investigate the role and mechanism of tubiquitin-conjugating enzyme E2 C (UBE2C) in acute myeloid leukemia (AML). Initially, UBE2C expression in leukemia was analyzed using the Cancer Genome Atlas database. Further, we silenced UBE2C expression using small-hairpin RNA (sh-RNA).

11p vishanshan 27-06-2024 1 1   Download

The winged-helix domain within the N-terminus of human MUS81 has been considered as potential target for drug development since the inhibition of this protein might significantly enhance the sensitivity of various cancer cells towards anticancer drugs. Nine cytotoxic triterpenoids previously purified from Helicteres hirsuta and Pterospermum truncatolobatum were selected for the docking experiment.

6p dianmotminh02 03-05-2024 1 1   Download

Ebook "Virus protein and nucleoprotein complexes" commences with a broad overview that places emphasis on virus assembly, followed by the capsid proteins of spherical viruses, helical virus nucleocapsids and viral envelope fusion. Then this book includes 16 more specific chapters dealing with the following: the ribonucleoprotein complex of negative-sense single-stranded RNA viruses;...

443p tracanhphuonghoa1007 22-04-2024 5 3   Download

Exome sequencing (ES) has been successfully applied in clinical detection of single nucleotide variants (SNVs) and small indels. However, identification of copy number variants (CNVs) using ES data remains challenging. The purpose of this study is to understand the contribution of CNVs and copy neutral runs of homozygosity (ROH) in molecular diagnosis of patients referred for ES.

17p vibransone 28-03-2024 3 1   Download

Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making it difficult to develop both screenings and effective treatments.

20p vibransone 28-03-2024 3 2   Download

In the present study, we investigated the expression profile of tDRs in plasma of CRC patients. The results showed that the level of 5′-tRF-GlyGCC is higher in CRC patients than in healthy controls (HCs) and highlighted that 5′- tRF-GlyGCC is a promising diagnostic biomarker for CRC patients. Its expression is positively correlated with ALKBH3 both in vitro and in vivo, respectively.

12p vibransone 28-03-2024 2 2   Download

ung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance and failure. Single-cell RNA sequencing (scRNA-seq) has been widely used to dissect the cellular composition and characterize the molecular properties of cancer cells and their tumor microenvironment in lung cancer.

18p viellison 28-03-2024 2 2   Download

In ebook "Molecular biology" plant biology is considered from the perspective of plants and their surrounding environment, including both biotic and abiotic interactions. The intended audience is undergraduate students in the middle or final phases of their programs of study.

427p cotieubac1004 15-03-2024 5 0   Download

Immunotherapy has revolutionized cancer treatment, but most patients are refractory to immunotherapy or acquire resistance, with the underlying mechanisms remaining to be explored. Methods We characterized the transcriptomes of ~92,000 single cells from 3 pre-treatment and 12 post-treatment patients with non-small cell lung cancer (NSCLC) who received neoadjuvant PD-1 blockade combined with chemotherapy.

25p vicwell 29-02-2024 4 1   Download

Ebook "Elucidation of abiotic stress signaling in plants: Functional genomics perspectives, Volume 2" provides timely research in the fi eld of stress-mediated signaling to develop a better and holistic understanding of stress perception and its transduction followed by the generation of response. In spite of the advent of different approaches to develop stress-tolerant crops towards multiple stress conditions in the fi eld, the success in achieving this goal is still unsatisfactory.

497p manmanthanhla0201 26-02-2024 2 1   Download

Ebook "Progress in Botany 71: Genetics physiology systematics ecology" provides readers with contents including: a journey with plant cell division - reflection at my halfway stop; replication of nuclear DNA; endoreduplication and growth of fleshy fruits; adaptation to a changing environment - the regulatory role of small RNAs; growth responses of trees to arctic light environment;...

418p tachieuhoa 28-01-2024 7 2   Download

Part 1 book "Animal models and human reproduction" includes content: Anatomy of the reproductive system; anatomy of mammalian (endocrine) glands controlling the reproduction; models for investigating placental biology; early developmental programming of the ovarian reserve; ovarian function, and fertility; small non coding RNAS in gametogenesis; the ovarian follicle of cows as a model for human,... and other contents.

248p muasambanhan04 07-01-2024 3 2   Download

Ebook "Epigenetic memory and control in plants" highlights recent advances in our understanding of epigenetic mechanisms as a major determinant through which internal and external signals, such as those occurring during hybridization, flowering time, reproduction and response to stress, communicate with plant cells to bring about activation of multiple nuclear processes and consequently plant growth and development. The outcome of these processes may persist for generations long after the initial cues have expired and may contribute to plant evolution.

264p lucchinguyen 28-12-2023 5 2   Download

Ebook "Argonaute proteins: Methods and protocols" aids researchers in examining these versatile proteins in a wide variety of cell types; features practical, step-by-step protocols which open the door to future progress in the field of molecular therapeutics; contains expert tips and vital implementation advice to ensure success;...

262p lucchinguyen 28-12-2023 5 2   Download

Ebook "RNA activation" offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).

238p lucchinguyen 28-12-2023 3 2   Download

Ebook "The retinoblastoma protein" covers the mechanisms of pRb inactivation detailing repressive mechanisms commonly associated to cancer, and representative of the experimentally relevant tests used in the establishment of cancer diagnosis and prognosis. Chapters contain protocols and in-depth discussions for commonly used experimental approaches to assess the status and function of components of the pRb pathway, including pRb itself, in cell lines and biological samples.

205p lucchinguyen 28-12-2023 5 2   Download

Pancreatic ductal adenocarcinoma (PDAC), constituting 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. Lack of early detection of PDAC contributes to its poor prognosis as patients are often diagnosed at an advanced stage of disease.

17p vileonardodavinci 23-12-2023 4 4   Download

An increasing number of small nucleolar RNA host genes (SNHGs) have been revealed to be dysregulated in lung cancer tissues, and abnormal expression of SNHGs is significantly correlated with the prognosis of lung cancer. The purpose of this study was to conduct a meta-analysis to explore the correlation between the expression level of SNHGs and the prognosis of lung cancer.

21p vileonardodavinci 23-12-2023 3 2   Download

Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The transfer RNA-derived fragments (tRFs) are a new group of small noncoding RNAs, which are dysregulated in many cancers. Until now, the expression and function of tRFs in glioma remain unknown.

18p vialfrednobel 23-12-2023 8 3   Download

As the dominant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in tumor progression. An increasing number of studies have confirmed that CAFs are involved in almost every aspect of tumors including tumorigenesis, metabolism, invasion, metastasis and drug resistance, and CAFs provide an attractive therapeutic target.

15p vischultz 20-10-2023 5 2   Download