Synthesis of chalcone derivatives

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Synthesis of 1, 3-diaryl-2-propene-1-one derivatives using Tripotassium phosphate as an alternative and efficient catalyst and study its cytotoxic and antimicrobial properties

A series of fourteen chalcone was synthesized via. Claisen–Schmidt condensation between substituted 2- hydroxyl acetonaphthones and substituted benzaldehyde in presence of tripotassium phosphate (K3PO4) catalyst.

16p tocectocec 25-05-2020 8 1 Download

Summary of organic chemistry doctoral thesis: Design, synthesis and evaluation of acetylcholinesterase inhibitory activity of chalcone derivatives for the discovery of new anti-alzheimer drugs

The objectives of the thesis: Molecular docking studies on acetylcholinesterase were performed to predict the chalcone structure has good in silico AChE acetylcholinesterase inhibitory activity. The potential chalcone compounds were synthesized and studied for their in vitro and in vivo AChE inhibitory activities

25p xacxuoc4321 09-07-2019 40 7 Download